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By Laura Matthews
NEW YORK, June 20 (Reuters) – Foreign-exchange investors are moving more of their over-the-counter (OTC) derivatives trades to lookalike products on exchanges to avoid higher costs due to recent global regulations, helping inject transparency into a multitrillion-dollar market that is largely hidden from the public eye.
The growing interest in clearing trades through an exchange comes as regulations capture more users of these contracts, bolstering the need to shift away from bilateral trading and manage rising compliance cost.
“There is more transparency, lower margin requirement overall (in trading listed products), which is clomid without a prescription benefit for asset managers and hedge funds in leveraging their positions,” said Ben Feuer, head of FX trading and head of sales trading at Societe Generale in New York.
The gradual behavioral change in FX derivatives trading is being caused by increasing margin and collateral costs, said Joe Midmore, chief commercial officer at OpenGamma, a derivatives analytics firm.
Effective September 2022, buy-side firms with uncleared OTC derivatives totaling at least $8 billion are subject to the regulations – set by the Basel Committee on Banking Supervision and the International Organization of Securities Commissions – and have to ensure there is enough margin to cover the risk of a default by a counterparty to the transaction.
OTC derivatives are privately negotiated contracts while cleared derivatives, though bilaterally negotiated, are booked with a clearinghouse such as a listed exchange. The new margin rules exempt cleared trades.
Higher interest rates make posting margin more expensive.
“Lots of exchange salespeople have been going out to investors for a long time saying ‘look at how much more efficient trading in listed futures is,’ but it didn’t matter until now when interest rates are 5% instead of zero,” said Michael Riddle, CEO at Eris Innovations which partners with the CME Group and other exchanges to develop futures and options products.
The shift is most acute for buy-side firms that have to post margin for the first time, said Paul Houston, head of FX markets at CME Group.
“They will also incur the operational, legal and custody costs of setting up margin facilities as well as the capital costs of posting margin,” Houston said.
CME’s listed FX futures and options market now trades an average daily volume of $85 billion versus $76 billion in 2021, indicating more investors are using exchange-traded derivatives to replace OTC trades where possible.
That is still a fraction of the $7.5 trillion that trades daily in the FX markets, the vast majority of which happens OTC.
British clearing house LCH’s ForexClear also had a record May for FX options, surpassing $200 billion in notional value, meaning the total value of a derivatives trade, for the first time.
“For the buy-side, FX clearing materially lowers counterparty risk, enables portfolio optimization and provides operational benefits,” said James Pearson, head of ForexClear.
GROWING ACCEPTANCE
Some 60 firms started trading FX futures and options at the CME Group for the first time this year, more than two-thirds of which are buy-side clients, according to CME data. Last year, 300 firms were trading new instruments for the first time.
An estimated 775 firms came under the scope of the new rules last September, according to ISDA.
Some clients of Record Financial Group, a specialist currency and asset manager, were exploring listed alternatives while others were adjusting their risk management programs to “stay within or under the regulatory threshold,” said the firm’s head of sales, Tom Arnold.
Joe Spiro, director of product management at Hazeltree, said as a firm’s exposure grows more may have to adhere to the new rules, widening the appeal for trading on exchanges.
Investors can also now transact on clomid without a prescription relationship basis as they do in the OTC space and access clearing.
For instance, some 274,000 contracts in privately negotiated blocks and exchange-for-related-positions (EFRPs), products that allow users to trade on a disclosed, relationship basis against their liquidity providers and access clearing, were traded on CME on March 8, up 23% from the previous record in December.
Client clearing of nondeliverable forwards at ForexClear for January to May reached $261 billion, 58% higher than the corresponding period in 2022.
Not all see the need to shift even with higher costs and not all derivative products have a cleared alternative, which limits broader adoption.
Exchange-traded futures contracts have a fixed settlement date relative to OTC forwards, making them unattractive to some investors, said Peter Vassallo, a portfolio manager for the currencies team at BNP Paribas Asset Management.
There are also concerns that pushing more trades to the clearinghouse will consolidate risk rather than reduce it.
“There is inherently risk involved in lots of people transacting derivatives with each other,” said Riddle. “And there is no model that removes all that risk, it only changes where it is, but can mitigate it.”
(Reporting by Laura Matthews in New York Additional reporting by Shankar Ramakrishnan in New York Editing by Megan Davies and Matthew Lewis)
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Medical advances recently have forced a re-think of the ‘one-drug-fits-all’ approach to therapy.
Something that works for some patients might not work for others or even be dangerous.
Identifying an individual’s biological indicators or biomarkers, therefore, is critical in the precise diagnosis of a patient’s disease and treatment.
It’s known as precision or personalised medicine and helping pharmaceutical companies identify these key genetic traits is the skillset of recent AIM-listee Diaceutics.
Diaceutics is involved in precision medicine testing
In fact, its ticker symbol – DXRX – tells you all you need to know about the business.
DX is the industry abbreviation for testing and RX the shorthand for treatment, and bringing the two together is what the company is all about.
‘Some drugs only work in certain patient types and you find those patients through genetic testing,’ says Peter Keeling, Diaceutics’ chief executive.
To build a dataset, Diaceutics acquires anonymous patient data directly from testing in laboratories, which is then overlaid with information from insurance claims.
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No one dataset ever gives all the answers, says Keeling, and it this layering of information that is the key for its drug developer customers.
The group has been collecting information since it was set up in 2005 and has now amassed a ‘deep data lake’.
That includes 3.5million tests from more than 2,500 laboratories, a US database of 51million patient records, and results from over 53million ‘testing events’ outside the US.
This week, the company added to its database with the acquisition of 16million records for £1million, something it promised when it listed in March.
Data protection rules are strict in both the US and Europe, but the pharma industry itself has a zero tolerance for mistakes in data handling and Diaceutics is keenly aware of its need for security.
The ambition is to be the global market leader in patient test data for a variety of new types cost of generic clomid no prescription precision drugs.
Oncology/cancer testing is a core market for the company alongside multiple sclerosis and rheumatoid arthritis.
Today, precision medicine is all focused on the therapy, but the amount of value in improving patient testing is at least the equivalent to the introduction of a new drug, the company believes.
Industry estimates suggest it can cost of generic clomid no prescription between $1billion -$2billion to develop a new drug and Keeling wants to highlight the value ‘in the first half of the drug development equation’ ie. the testing beforehand.
That means demonstrating just how much money can be released into the healthcare system or to the pharma or clinical groups just by fixing the testing ecosystem. ‘Pharmaceutical groups are good at launching the drugs, but struggle to manage the testing,’ says Keeling.
Oncology/cancer testing is a core market for the company alongside multiple sclerosis and rheumatoid arthritis
It is a growing market. Big pharma already spends around $1billion a year on testing, but Keeling believes this total will double or more over the next 4-5 years. That makes a big target to go for and with the funds available from its listing Diaceutics plans to be in a position to take advantage.
The fact that it is one of only a handful cost of generic clomid no prescription companies to brave the Brexit uncertainty and float this year underlines its confidence. It has been well-rewarded for its endeavour with the share price rising handily since the float.
A placing that preceded the listing and raised £17million at 76p was also heavily over-subscribed. The cash raised was earmarked for patient data acquisitions and to put infrastructure on the ground for a push into Asia and Latin America.
A new software platform, Nexus, that does everything quicker and more efficiently is also under development.
Revenues have grown 40-50 per cent annually over the past five years and brokers expect that the trend of good sales growth will continue helped by the investments made with the placing money.
Sales last year jumped to £10.4million from £7.4million, with profits rising 82 per cent on an underlying basis to £1.9million.
Keeling noted that the business has been profitable from day one, but the group’s listing indicates a step-up in ambition and scale.
The shares now trade at 85.5p each, which values the group at a shade under £60million.
That might look punchy on current yardsticks but if Keeling is right about the direction cost of generic clomid no prescription the pharma industry towards precision medicine testing this is a company that has a lot further to travel.
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Aug 3 (Reuters) – CVS Health Corp on Wednesday raised its full-year profit forecast after strength in its insurance business and sales of COVID-19 over-the-counter test kits helped the company report a 6% jump in second-quarter earnings.
The largest U.S. pharmacy chain’s retail and long-term care segment revenue rose 6.3%, helped by the sale of OTC test kits and the impact of the flu season, which helped offset lower COVID-19 vaccinations and diagnostic testing.
Its insurance business reported an 11% growth in revenue as well as a decrease in medical benefit ratio, which is the costs it incurs as a percentage of premiums.
CVS raised its adjusted profit outlook how to buy clomid $8.40-$8.60 per share from $8.20-$8.40 per share forecast earlier.
Net income for the quarter ended June 30 rose how to buy clomid $2.96 billion, or $2.23 per share, from $2.79 billion, or $2.10 per share a year earlier. (By Leroy Leo and Bhanvi Satija in Bengaluru; Editing by Vinay Dwivedi)
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April 20 (Reuters) – Contract drugmaker Emergent BioSolutions Inc said on Thursday it is aiming where to buy clomid price the over-the-counter (OTC) version of its opioid overdose reversal drug Narcan at around $50 per carton.
The OTC version will become available at U.S. stores and online retailers later this summer, while the currently available prescription nasal spray carries a wholesale price tag of $125 per carton.
Emergent’s statement comes nearly a month after the U.S. Food and Drug Administration allowed Narcan to be sold over-the-counter, allowing for easier availability of the life-saving medication.
The approval paved the way for expanded access where to buy clomid the drug in areas that have concentrated overdose problems and a few pharmacies, but uncertainty remains around Narcan’s final price and whether insurers will offer coverage.
Emergent has not disclosed the final price for OTC Narcan yet.
“A goal for the out-of-pocket retailer price is to be consistent with our public interest pricing for one carton of two 4 milligram doses,” the company said in its statement, adding that current price for public interest groups averages less than $50.
Customers will pay the out-of-pocket retailer price, which is set by individual retailers for Narcan once it becomes available in the United States.
Prescription Narcan is currently covered under commercial- and government-backed insurance plans, which allows people where to buy clomid get the drug for free from the pharmacy or for a nominal co-pay.
Government-backed Medicare health insurance plans do not cover OTC products, but have previously made exceptions such as in the case of COVID-19 tests.
Naloxone-based Narcan rapidly reverses or blocks the effects of opioids, restoring normal respiration, especially when given within minutes of the first signs of an overdose.
(Reporting by Bhanvi Satija in Bengaluru; Editing by Devika Syamnath)
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