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LME to commission independent review of nickel market chaos

April 4 (Reuters) – The London Metal Exchange said on Monday it would commission an independent review into the events that led to chaos in the nickel market last month, and said it had introduced daily price limits for all its metals.

The LME, the world’s oldest and largest market for industrial metals, last month brought in 15% upper and lower daily price limits for all of its physically delivered metals plus cash-settled cobalt.

The exchange suspended nickel trading on March 8 after prices spiked by more than 50% to hit $100,000 a tonne. Activity resumed on March 16 when it launched daily price limits and the provision of clomid otc nickel trading data for the first time.

The price surge was blamed on short-covering by one of the world’s top nickel producers, China’s Tsingshan Holding Group. The LME has said the large short positions originated primarily from the over-the-counter (clomid otc) market.

The exchange also said it wanted to introduce clomid otc trade reporting across the board and that a first step was to extend provision of clomid otc daily position reporting, as is now implemented for nickel, to other metals.

The LME said it welcomed an announcement by British financial regulators who said on Monday that they would review the way the exchange handled the halt in nickel trading last month.

It added that it would also commission an independent review of events leading up to the trading suspension in an attempt to prevent a repeat of such a situation. (Reporting by Swati Verma in Bengaluru; Editing by David Goodman,Pravin Char and David Evans)

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FDA presses pause on trial for OTC version of anti-impotence drug…

By Tassilo Hummel and Natalie Grover

PARIS/LONDON, May 30 (Reuters) – The U.S. health regulator has put on hold a trial designed to evaluate switching the prescription-only erectile dysfunction drug Cialis to an over-the-counter (OTC) treatment, French drugmaker Sanofi said on Monday.

The pause is related to concerns about how the trial protocol has been designed, the company said, adding that no patients had so far been recruited for the study.

Cialis, known chemically as tadalafil, was first approved by the European Medicines Agency in 2002 and then by the U.S. Food and Drug Administration (FDA) in 2003 as a prescription-only therapy.

The treatment – which made developer U.S. drugmaker Eli Lilly billions before generic competition eroded sales – has differentiated itself from competition because it has a time-release formula that allows men to take it anywhere up to 36 hours before they use it.

In 2014, Sanofi won the license to sell Cialis as a non-prescription drug in the United States, Europe, Canada and Australia, once regulatory approvals have been secured in each region.

This OTC version cost of generic clomid Cialis is expected to be a key contributor to achieving above-market growth from 2024 in Sanofi’s consumer health division, a company executive said last year.

Any delays here are clearly unhelpful, Bernstein analyst Wimal Kapadia told Reuters, adding that it was unclear what the delay would mean for that 2024 timeline.

Sanofi’s stock was down more than 3% by late morning on Monday.

When determining whether to allow prescription drugs to be sold over the counter, the FDA weighs whether patients are able to understand complex aspects cost of generic clomid their condition and exactly when to take the drug to ensure safe use.

Like rival anti-impotence drugs, such as Viagra, Cialis can cause a dangerous fall in blood pressure if taken with nitrates, a class of heart drugs that include nitroglycerine.

The global erectile dysfunction treatment market was estimated to be worth roughly $3.7 billion last year, and is expected to grow to about $5.9 billion by 2028, according to market intelligence firm Coherant Market Insights, though it was unclear what slice cost of generic clomid the market was expected to be taken by OTC drugs. (Reporting by Tassilo Hummel in Paris and Natalie Grover in London; additional reporting by Juliette Portala in Gdansk; Editing by Bradley Perrett and David Holmes)

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U.S. FDA staff flag no new safety concerns for OTC opioid overdose…

By Bhanvi Satija

Feb 13 (Reuters) – The U.S. Food and Drug Administration’s staff reviewers on Monday did not flag any new safety concerns related to Emergent BioSolutions Inc’s over-the-counter version of nasal spray Narcan for reversing opioid overdose.

The FDA’s advisory panel will meet on Wednesday to discuss the first OTC version of Narcan, or naloxone, used to prevent death by overdose.

One advantage of switching to OTC could be reducing the chance of mistakenly using it for other conditions, the reviewers said.

“For the nonprescription product, patients will have to select the product for the suspected or known opioid overdose off the shelf,” said staff reviewers in briefing documents published on the agency’s website.

Some experts were optimistic that a favorable vote from the committee could make an impact on the overdose crisis.

“It’s not sufficient, but it is a piece of the puzzle we need to put in place,” said Maryann Mason, Associate Professor at Northwestern University’s Feinberg School of Medicine.

The panel is expected to weigh in on how to improve labeling of Emergent’s Narcan to ensure safe and effective use by a consumer in an emergency situation.

“Labeling with an idea to limited literacy is a good idea. So it will be important to make pictorials and other aides available,” added Mason.

FDA approval for where buy cheap clomid OTC Narcan could increase its availability and would align the federal government’s stance with that of various states that have provisions to offer Narcan or naloxone without prescriptions through a pharmacist.

However, some doctors cautioned against prescription-free use of naloxone, which rapidly reverses or buying generic clomid blocks the effects of opioids, citing the need for professional oversight.

“It must be given just by professional people as patients might need medical supervision immediately after,” said Dr. Andre Waismann, founder of Accelerated Neuro-Regulation Clinics. (Reporting by Bhanvi Satija and Pratik Jain in Bengaluru; Editing by Dhanya Ann Thoppil, Devika Syamnath and Krishna Chandra Eluri)

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