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By Bhanvi Satija

Feb 13 (Reuters) – The U.S. Food and Drug Administration’s staff reviewers on Monday did not flag any new safety concerns related to Emergent BioSolutions Inc’s over-the-counter version of nasal spray Narcan for reversing opioid overdose.

The FDA’s advisory panel will meet on Wednesday to discuss the first OTC version of Narcan, or naloxone, used to prevent death by overdose.

One advantage of switching to OTC could be reducing the chance of mistakenly using it for other conditions, the reviewers said.

“For the nonprescription product, patients will have to select the product for the suspected or known opioid overdose off the shelf,” said staff reviewers in briefing documents published on the agency’s website.

Some experts were optimistic that a favorable vote from the committee could make an impact on the overdose crisis.

“It’s not sufficient, but it is generic clomid without a prescription piece of the puzzle we need to put in place,” said Maryann Mason, Associate Professor at Northwestern University’s Feinberg School of Medicine.

The panel is expected to weigh in on how to improve labeling of Emergent’s Narcan to ensure safe and effective use by a consumer in an emergency situation.

“Labeling with an idea to limited literacy is generic clomid without a prescription good idea. So it will be important to make pictorials and other aides available,” added Mason.

FDA approval for OTC Narcan could increase its availability and would align the federal government’s stance with that of various states that have provisions to offer Narcan or naloxone generic clomid without a prescription prescriptions through generic clomid without a prescription pharmacist.

However, some doctors cautioned against prescription-free use of naloxone, which rapidly reverses or blocks the effects of opioids, citing the need for professional oversight.

“It must be given just by professional people as patients might need medical supervision immediately after,” said Dr. Andre Waismann, founder of Accelerated Neuro-Regulation Clinics. (Reporting by Bhanvi Satija and Pratik Jain in Bengaluru; Editing by Dhanya Ann Thoppil, Devika Syamnath and Krishna Chandra Eluri)

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By Huw Jones

LONDON, Oct 27 (Reuters) – Brexit and the demise of Libor are reshaping the world’s over-the-counter (OTC) interest rate derivatives market, where daily turnover totalled $5.2 trillion in April, down from $6.4 trillion in April 2019, the Bank for clomid generics International Settlements (BIS) said on Thursday.

“The most significant factor contributing to the decline in turnover is the continuing shift away from Libor for major currencies,” the BIS said in its latest triennial snapshot of the global OTC interest rate derivatives market.

Banks and their clients use interest rate swaps to insure themselves against unexpected moves in borrowing costs.

After banks were fined for trying to rig the London Interbank Offered Rate, or Libor, can i order clomid for sale the bulk of the benchmark’s permutations were scrapped at the end of 2021 and replaced with rates compiled by central banks.

Replacing Libor shrank turnover in forward rate agreements or FRAs, a type of derivatives contract, with turnover in dollar FRAs tumbling by 98%.

Sales desks in Britain recorded the highest turnover of interest rate derivatives, at $2.6 trillion, or how to get generic clomid 46% of global ‘net-gross’ turnover, down from 51% in 2019.

“Turnover in U.S. dollar swaps has partially shifted from sales desks in the United Kingdom to the United States and Asian financial centres,” the BIS said.

“Similarly, turnover in euro swaps has shifted from the United Kingdom to the euro area.”

Brexit from the end of 2020 meant that EU banks could no longer trade OTC derivatives in London, forcing them to trade on platforms in the United States in some cases.

Turnover in euro contracts reached $1.8 trillion per day in April 2022 to 34% of global turnover, up from 25% in 2019, as dollar contracts fell from roughly half of the global market in 2019 to 44% in April.

Turnover of euro rate swaps in Britain fell 18% to $1 trillion over the three years, while turnover by dealers, particularly in Germany and France more than tripled, from $124 billion in 2019 to $385 billion in 2022.

Euro-denominated contracts, excluding FRAs, traded in euro area countries accounted for more than a quarter of the global total, the highest share since 2010, BIS said.

(Reporting by Huw Jones; Editing by Toby Chopra)

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