Adobe White Rabbit crack

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Adobe White Rabbit Crack

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The procedure was similar to that used by Clarke et al. [ 36 ] and was conducted under aseptic conditions. Rabbits were sedated and anaesthetised using a neuroleptanalgesic, Hypnorm (VetaPharma Ltd., Leeds, UK), administered intramuscularly at 0.25mL/kg and midazolam (HYPNOVEL, Roche Products Ltd., Welwyn Garden City, UK), which was administered intravenously at 0.51.5mg/kg. Both hind limbs were prepared for surgery by shaving, draping and swabbing the surgical site with a chlorhexidine based antimicrobial agent (ChloraPrep, CareFusion UK 306 Ltd., Basingstoke, UK). An incision (~3cm) was made medial to the patella, allowing lateral dislocation of the patella. The femoral condyle was visualised and a defect matching the size of the implant created by reaming with a custom made hand-held steel drill. Prior to implantation the defect was lavaged with a saline solution to remove any bone debris, bone marrow and/or blood from the cavity. The implant was then inserted into the defect so that the base of the cone was flush with the cortical bone before the patella was reduced. The incision was closed in two layers; the subcutaneous layer was sutured with an interrupted pattern using absorbable sutures (Coated VICRYL, Ethicon Inc., Livingston, UK); the same sutures were used to close the skin using a continuous subcuticular pattern (Fig. 2 ).
-TCP-CPC was produced following a previously described protocol [ 24 ] and shaped using polytetrafluoroethylene (PTFE) moulds. Conical cement samples, 8mm high with a base diameter of 4mm (Fig. 1 ), were produced for ease of implantation and because such geometry has been suggested for prediction of resorption by evaluating the short term resorption profiles [ 30 ]. A conical sample also has the advantage of more closely replicating the variable thickness of cement that would result from injection into vertebral cracks. Although such cements are injected minimally invasively and set in situ clinically, using pre-formed samples allowed precise control over sample geometry which facilitated analysis and comparisons.
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