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Eukaryotic cells respond to many physiological and pathological signals through the phosphorylation of the transcription factor β-catenin. β-catenin, in turn, activates the expression of target genes such as cyclin D1, which is critical for the regulation of cell proliferation. Several recent studies have shown that cells can engage in an intracellular signaling circuit involving the endoplasmic reticulum (ER)-located proteins (PERK, IRE1, and ATF6) that modulates the response to ER stress. We have found that the Wnt3a-induced Wnt/β-catenin signaling pathway leads to the transcriptional activation of cyclin D1 in human colon cancer cells. Here we have explored the mechanism by which this pathway is controlled. We observed that Wnt3a signaling triggers the dissociation of beta-catenin from Axin in a complex with APC. This dissociation is believed to have important consequences for the regulation of β-catenin-dependent transcription by allowing the translocation of β-catenin into the nucleus. The activation of APC by Wnt3a was found to be dependent on the dissociation of APC from Axin. The modulation of the Wnt3a-dependent β-catenin signaling was found to be associated with a sharp increase in the protein levels of two ER transmembrane proteins http://chinesemedicineevents.com/wp-content/uploads/2022/06/Falkon_formerly_QupZilla.pdf
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