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the histologic changes of the primary melanomas in the PC and the sphenoid sinus of the same patient. Keywords: chemokine (cxc ligand 4); metalloprotease (recombinant); tissue. It has therefore been suggested that chemokine ligand 4, (Cxe2x88x92C motif) plays a role in melanoma migration and invasion. (Pampaloni, G. and B.J… The chemokine, (Cxe2x88x92C motif) ligand 4 (CCL4), is a potent chemoattractant for monocytes and macrophages. However, both Th1 and Th2 chemokines, i.e., CCL2 and CCL4, have been detected in tissue specimens of melanomas. (Rouffar, M. and A. Oukka, 1995, Biochem. Biophys. Res. Commun. 2, 1148, and Ambrosio, A. et al., 1999, Leuk. Lymphoma. 40, 56). The expression of many different chemokines, such as CCL2 and CCL5, Cxe2x88x92C motif chemokine receptor 4 (CCR4), was shown to occur in lung cancer cells, and these chemokines/receptors have been associated with lung cancer malignancy. (Khalil, M. L., et al., 1999, Biochem. Biophys. Res. Commun. 257, 719; Riedel, C. T., et al., 1999, J. Leukoc. Biol. 65, 787; Zhang, L. P., et al., 1996, J. Biol. Chem. 271, 11045; Cohen, B., et al., 1999, J. Biol. Chem. 274, 21476). The human oncostatin-M has been identified in a supernatant from the murine plasmacytoma cell line, SPPC/0 as a Cxe2x88x92C motif chemokine ligand, Cxe2x88x92C motif chemokine receptor 3 (CCR3) is a high-affinity G-protein-coupled receptor. Oncostatin-M was found to increase the migration of erythroid colonies from adult mouse bone marrow but not from fetal mouse bone marrow (Durand, J. M. et al
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