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USD/INR monthly futures expiry fuels demand for dollars -traders

By Nimesh Vora

MUMBAI, Sept 28 (Reuters) – The imminent expiry of the USD/INR monthly futures contract has led to higher demand for dollars in the over-the-counter (OTC) market, traders said on Wednesday.

The NSE September futures contract is set to expire at noon.

Banks, who had build positions in OTC and in futures to take advantage of arbitrage opportunities, were offering a premium to buy cheap clomid dollars at the Reserve Bank of India reference rate.

The futures leg of the contract expires automatically at the RBI reference rate, but the OTC leg needs to closed by buying or selling dollars.

The premium that traders were willing to pay to buy cheap clomid dollars at the Reserve Bank of India reference rate, rose to as much as 0.04 rupees, compared to almost par or 0.01 in recent weeks, a trader at a private sector bank said.

This means that if the RBI reference rate was fixed at 81.88 on Wednesday, the actual transaction price will be 81.92.

“There is demand from foreign banks for buying (dollars) at the fixing rate, probably related to offshore (clients),” the trader said.

“The squaring of futures-OTC arbitrage position is one more reason for the demand.”

The open interest on the contract was at around $2.2 billion, down about $150 million from the previous session.

Meanwhile, the Indian rupee dropped to a record low of 81.9350, down from 81.58 in the previous session.

The RBI likely sold dollars via state-run banks to slow the pace of rupee’s fall, traders said. (Reporting by Nimesh Vora; Editing by Neha Arora)

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Forex derivatives nudged out into the open as regulations increase…

By Laura Matthews

NEW YORK, June 20 (Reuters) – Foreign-exchange investors are moving more of their over-the-counter (OTC) derivatives trades to lookalike products on exchanges to avoid higher costs due to recent global regulations, helping inject transparency into a multitrillion-dollar market that is largely hidden from the public eye.

The growing interest in clearing trades through an exchange comes as regulations capture more users of these contracts, bolstering the need to shift away from bilateral trading and manage rising compliance cost.

“There is more transparency, lower margin requirement overall (in trading listed products), which is a benefit for asset managers and hedge funds in leveraging their positions,” said Ben Feuer, where can i buy clomid head of FX trading and head of sales trading at Societe Generale in New York.

The gradual behavioral change in FX derivatives trading is being caused by increasing margin and collateral costs, said Joe Midmore, chief commercial officer at OpenGamma, a derivatives analytics firm.

Effective September 2022, buy-side firms with uncleared OTC derivatives totaling at least $8 billion are subject to the regulations – set by the Basel Committee on Banking Supervision and the International Organization of Securities Commissions – and have to ensure there is enough margin to cover the risk of a default by a counterparty to the transaction.

OTC derivatives are privately negotiated contracts while cleared derivatives, though bilaterally negotiated, are booked with a clearinghouse such as a listed exchange. The new margin rules exempt cleared trades.

Higher interest rates make posting margin more expensive.

“Lots of exchange salespeople have been going out to investors for a long time saying ‘look at how much more efficient trading in listed futures is,’ but it didn’t matter until now when interest rates are 5% instead of zero,” said Michael Riddle, CEO at Eris Innovations which partners with the CME Group and other exchanges to develop futures and options products.

The shift is most acute for buy-side firms that have to post margin for the first time, said Paul Houston, head of FX markets at CME Group.

“They will also incur the operational, legal and custody costs of setting up margin facilities as well as the capital costs of posting margin,” Houston said.

CME’s listed FX futures and options market now trades an average daily volume of $85 billion versus $76 billion in 2021, indicating more investors are using exchange-traded derivatives to replace OTC trades where possible.

That is still a fraction of the $7.5 trillion that trades daily in the FX markets, the vast majority of which happens OTC.

British clearing house LCH’s ForexClear also had a record May for FX options, surpassing $200 billion in notional value, meaning the total value of a derivatives trade, for the first time.

“For the buy-side, FX clearing materially lowers counterparty risk, enables portfolio optimization and provides operational benefits,” said James Pearson, head of ForexClear.

GROWING ACCEPTANCE

Some 60 firms started trading FX futures and options at the CME Group for the first time this year, more than two-thirds of which are buy-side clients, according to CME data. Last year, 300 firms were trading new instruments for the first time.

An estimated 775 firms came under the scope of the new rules last September, according to ISDA.

Some clients of Record Financial Group, a specialist currency and asset manager, were exploring listed alternatives while others were adjusting their risk management programs to “stay within or under the regulatory threshold,” said the firm’s head of sales, cheap clomid without rx Tom Arnold.

Joe Spiro, director of product management at Hazeltree, said as a firm’s exposure grows more may have to adhere to the new rules, widening the appeal for trading on exchanges.

Investors can also now transact on a relationship basis as they do in the OTC space and access clearing.

For instance, some 274,000 contracts in privately negotiated blocks and exchange-for-related-positions (EFRPs), products that allow users to trade on a disclosed, relationship basis against their liquidity providers and access clearing, were traded on CME on March 8, up 23% from the previous record in December.

Client clearing of nondeliverable forwards at ForexClear for January to May reached $261 billion, 58% higher than the corresponding period in 2022.

Not all see the need to shift even with higher costs and not all derivative products have a cleared alternative, which limits broader adoption.

Exchange-traded futures contracts have a fixed settlement date relative to OTC forwards, making them unattractive to some investors, said Peter Vassallo, a portfolio manager for the currencies team at BNP Paribas Asset Management.

There are also concerns that pushing more trades to the clearinghouse will consolidate risk rather than reduce it.

“There is inherently risk involved in lots of people transacting derivatives with each other,” said Riddle. “And there is no model that removes all that risk, it only changes where can i get clomid it is, but can mitigate it.”

(Reporting by Laura Matthews in New York Additional reporting by Shankar Ramakrishnan in New York Editing by Megan Davies and Matthew Lewis)

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U.S. FDA staff flag no new safety concerns for OTC opioid overdose…

By Bhanvi Satija

Feb 13 (Reuters) – The U.S. Food and Drug Administration’s staff reviewers on Monday did not flag any new safety concerns related to Emergent BioSolutions Inc’s over-the-counter version of nasal spray Narcan for reversing opioid overdose.

The FDA’s advisory panel will meet on Wednesday to discuss the first OTC version of Narcan, or naloxone, used to prevent death by overdose.

One advantage of switching to OTC could be reducing the chance of mistakenly using it for other conditions, the reviewers said.

“For the nonprescription product, patients will have to select the product for the suspected or known opioid overdose off the shelf,” said staff reviewers in briefing documents published on the agency’s website.

Some experts were optimistic that a favorable vote from the committee could make an impact on the overdose crisis.

“It’s not sufficient, but it is generic clomid without a prescription piece of the puzzle we need to put in place,” said Maryann Mason, Associate Professor at Northwestern University’s Feinberg School of Medicine.

The panel is expected to weigh in on how to improve labeling of Emergent’s Narcan to ensure safe and effective use by a consumer in an emergency situation.

“Labeling with an idea to limited literacy is generic clomid without a prescription good idea. So it will be important to make pictorials and other aides available,” added Mason.

FDA approval for OTC Narcan could increase its availability and would align the federal government’s stance with that of various states that have provisions to offer Narcan or naloxone generic clomid without a prescription prescriptions through generic clomid without a prescription pharmacist.

However, some doctors cautioned against prescription-free use of naloxone, which rapidly reverses or blocks the effects of opioids, citing the need for professional oversight.

“It must be given just by professional people as patients might need medical supervision immediately after,” said Dr. Andre Waismann, founder of Accelerated Neuro-Regulation Clinics. (Reporting by Bhanvi Satija and Pratik Jain in Bengaluru; Editing by Dhanya Ann Thoppil, Devika Syamnath and Krishna Chandra Eluri)

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Japan’s Takeda eyes new focus on vaccines after OTC asset sales-CEO

By Rocky Swift

TOKYO, Nov 6 (Reuters) – Japan’s Takeda Pharmaceutical Co is looking at making vaccines a core business after completing asset sales to lower debt following its takeover of Shire Plc, Chief Executive Christophe Weber said.

Japan’s biggest drugmaker by revenue recently completed $10 billion in sales of mostly over-the-counter drug assets to reduce debt after its $59 billion purchase of Shire, clomid without dr prescription saying it would focus on five key business areas.

With a dengue fever vaccine in development and deals to make and distribute COVID-19 vaccines in Japan, the company could add a new pillar to its business lineup, Weber said.

“We are in the vaccines business,” Weber told Reuters in an interview. “If the dengue vaccine is successful, yes, it would be a sixth one.”

Takeda’s current five core businesses are oncology, gastroenterology, neuroscience, rare diseases, and where to get clomid plasma-derived therapies.

The company looked into making a COVID-19 vaccine, but determined with its mix of technology and capacity, it was a better fit to work with other developers, Weber said.

Takeda agreed last month to distribute 50 million doses of Moderna Inc’s COVID-19 vaccine in Japan. That was on top of a previous deal to produce Novavax Inc’s COVID-19 candidate, aiming to make 250 million doses.

Takeda’s dengue vaccine candidate, clomid rx TAK-003, is on track for regulatory filing in Asia, Latin America, and the European Union by the end of fiscal 2020, the company said last month. The disease is spread by mosquitoes and order generic clomid is estimated to affect 50 million people a year worldwide with 22,000 deaths.

Following the Shire takeover, Takeda reached its asset disposal goal with the sale of its Japanese consumer healthcare business to Blackstone Group for 242 billion yen ($2.31 billion) announced in August.

The company was not eyeing any more major sell offs, Weber said, saying any such deals would be “very marginal.” (Reporting by Rocky Swift; editing by Jane Wardell)

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Emergent aims to price over-the-counter Narcan at about $50

April 20 (Reuters) – Contract drugmaker Emergent BioSolutions Inc said on Thursday it is aiming to price the over-the-counter (OTC) version of its opioid overdose reversal drug Narcan at around $50 per carton.

The OTC version will become available at U.S. stores and online retailers later this summer, while the currently available prescription nasal spray carries a wholesale price tag of $125 per carton.

Emergent’s statement comes nearly a month after the U.S. Food and Drug Administration allowed Narcan to be sold over-the-counter, allowing for easier availability of the life-saving medication.

The approval paved the way for expanded access to the drug in areas that have concentrated overdose problems and a few pharmacies, but uncertainty remains around Narcan’s final price and whether insurers will offer coverage.

Emergent has not disclosed the final price for order generic clomid OTC Narcan yet.

“A goal for the out-of-pocket retailer price is to be consistent with our public interest pricing for one carton of two 4 milligram doses,” the company said in its statement, adding that current price for cheap clomid without a prescription public interest groups averages less than $50.

Customers will pay the out-of-pocket retailer price, which is set by individual retailers for Narcan once it becomes available in the United States.

generic clomid without dr prescription Narcan is currently covered under commercial- and government-backed insurance plans, which allows people to get the drug for free from the pharmacy or for a nominal co-pay.

Government-backed Medicare health insurance plans do not cover OTC products, but have previously made exceptions such as in the case of COVID-19 tests.

Naloxone-based Narcan rapidly reverses or blocks the effects of opioids, restoring normal respiration, especially when given within minutes of the first signs of an overdose.

(Reporting by Bhanvi Satija in Bengaluru; Editing by Devika Syamnath)

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U.S. FDA issues warning to companies selling unapproved skin…

The U.S. Food and Drug Administration (FDA) said on Tuesday it sent warning letters to twelve companies for selling certain over-the-counter (OTC) skin lightening products which have not been approved by the agency and pose safety risks.

The products from companies including M & M Beauty and Wellness, Ultimark Products and cheap clomid without a prescription Genomma Lab USA contain hydroquinone, a depigmentation agent used in skin lightening creams which has come under the FDA’s scrutiny over safety concerns.

There is currently only one drug, Tri-Luma, clomid without prescription approved by the FDA which contains hydroquinone, the agency said. The Tri-Luma cream is a prescription product for the treatment of moderate-to-severe melasma, a pigmentation disorder.

The FDA said it has received reports of serious side effects including skin rashes and facial swelling from skin lightening products containing hydroquinone. website

It has advised people to not use such products as they may result in conditions such as ochronosis, a bluish-black or grey-blue discoloration of the skin, which could be permanent.

The agency also said OTC drugs skin lightening products containing skin lightening products containing hydroquinone need to be FDA approved before they can i get clomid be legally sold, as per reforms under the Coronavirus Aid, Relief and Economic Security (CARES) Act.

The FDA has asked the companies that received the warning letters to take prompt action and respond to the agency within 15 days. (Reporting by Amruta Khandekar; Editing by Krishna Chandra Eluri)

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U.S. FDA panel to discuss Perrigo’s daily OTC birth-control pill in…

March 28 (Reuters) – The U.S. Food and Drug Administration plans to hold an advisory panel meeting to discuss Perrigo Company Plc’s over-the-counter (OTC) birth control pill in May, cheap clomid prices the drugmaker said on Tuesday.

The panel will decide on recommending the non-estrogen contraceptive as a daily OTC birth control pill on May 9 and 10. The drug, Opill, is expected to be the first such pill in the United States if approved.

Opill, which has been used with a prescription since its approval in 1973, cheap clomid for sale was due for review in November last year, but the FDA delayed that meeting to review additional information.

Contraceptives have been in focus since abortion rights were curtailed in 2022 when the U.S. Supreme Court overturned the constitutional right to terminate pregnancies as it scrapped a landmark ruling in the 1973 Roe vs. Wade case.

(Reporting by Pratik Jain; Editing by Shinjini Ganguli)

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FDA may approve birth control pill WITHOUT prescription by summer

Come this summer, women could have access to birth control pills without a prescription for the first time in US history.

The Food and Drug Administration is weighing the merits of approving a type of over-the-counter birth control in use since the 1970s called Opill, a progestin-only pill that prevents unwanted pregnancies in about 94 percent of cases.

HRA Pharma presented real-world evidence Tuesday that showed the vast majority of eligible people took its pill correctly without negative consequences and followed the instructions without the help of a medical professional, a concern that FDA officers had about making it OTC.

The manufacturer of the FDA-approved prescription drug also reported that teenagers and people with less understanding of their health and the healthcare system were able to stick to their daily medication regimen, a strong sign that the populations most vulnerable to unplanned pregnancies would be well protected.

The debate about prescription-free birth control has been brewing for years but hit a boiling point last year following the groundbreaking decision by the Supreme Court to rescind the federal guarantee to abortion established 50 years ago.

HRA Pharma, the now owned by Perrigo approval for the first-ever birth control pill that women could buy without a prescription. The request from a French drugmaker sets up a high-stakes decision for the Food and Drug Administration amid the political fallout from the Supreme Court’s recent decision overturning Roe v Wade

Access to mifepristone, one of two pills in a medication abortion regimen, has become a fixture of the culture wars dictated by far-right conservative ideology.

While birth control is entirely and completely different from mifepristone, it has been swept up in the fight over abortion since Supreme Court Justice wrote that the court ‘should reconsider’ several precedents that concern the right to privacy—including the legality of contraception.

Approving Opill for use over the counter would widen birth control options for more than 19 million women living in areas of the US without reasonable access to a health center that offers the full range of contraceptive methods.

Roughly three dozen medical organizations including the American Medical Association, the American College of Obstetricians and Gynecologists (ACOG), and the American Academy of Family Physicians have been calling for a non-prescription birth control pill option for years.

Opill, also called the mini-pill, has been safely in use for about five decades, but the US is an outlier when it comes to making the pills available without a doctor’s order.

Opill contains progestin only, unlike many oral contraceptives that contain both progestin and estrogen.

This is the appeal of the mini-pill. Because it does not contain estrogen, which increases the risk of blood clotting by several-fold, can i order clomid the progestin-only pills is seen as lower-risk.

Its modus operandi is to thicken mucus in the cervix, making it difficult for sperm to enter the uterus and fertilize an egg.

Progestin-only pills do not prevent ovulation as well as combination birth control pills. Therefore, their effectiveness is slightly lower.

The FDA’s Nonprescription Drugs Advisory Committee and the Reproductive and clomid otc Urologic Drugs Advisory Committee had two primary concerns about designating Opill for over the counter use.

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Libor demise and Brexit reshape derivatives market, says BIS

By Huw Jones

LONDON, Oct 27 (Reuters) – Brexit and the demise of Libor are reshaping the world’s over-the-counter (OTC) interest rate derivatives market, where daily turnover totalled $5.2 trillion in April, down from $6.4 trillion in April 2019, the Bank for clomid generics International Settlements (BIS) said on Thursday.

“The most significant factor contributing to the decline in turnover is the continuing shift away from Libor for major currencies,” the BIS said in its latest triennial snapshot of the global OTC interest rate derivatives market.

Banks and their clients use interest rate swaps to insure themselves against unexpected moves in borrowing costs.

After banks were fined for trying to rig the London Interbank Offered Rate, or Libor, can i order clomid for sale the bulk of the benchmark’s permutations were scrapped at the end of 2021 and replaced with rates compiled by central banks.

Replacing Libor shrank turnover in forward rate agreements or FRAs, a type of derivatives contract, with turnover in dollar FRAs tumbling by 98%.

Sales desks in Britain recorded the highest turnover of interest rate derivatives, at $2.6 trillion, or how to get generic clomid 46% of global ‘net-gross’ turnover, down from 51% in 2019.

“Turnover in U.S. dollar swaps has partially shifted from sales desks in the United Kingdom to the United States and Asian financial centres,” the BIS said.

“Similarly, turnover in euro swaps has shifted from the United Kingdom to the euro area.”

Brexit from the end of 2020 meant that EU banks could no longer trade OTC derivatives in London, forcing them to trade on platforms in the United States in some cases.

Turnover in euro contracts reached $1.8 trillion per day in April 2022 to 34% of global turnover, up from 25% in 2019, as dollar contracts fell from roughly half of the global market in 2019 to 44% in April.

Turnover of euro rate swaps in Britain fell 18% to $1 trillion over the three years, while turnover by dealers, particularly in Germany and France more than tripled, from $124 billion in 2019 to $385 billion in 2022.

Euro-denominated contracts, excluding FRAs, traded in euro area countries accounted for more than a quarter of the global total, the highest share since 2010, BIS said.

(Reporting by Huw Jones; Editing by Toby Chopra)

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Hong Kong regulator sharpening scrutiny of derivatives after…

By Selena Li

HONG KONG, June 28 (Reuters) – Hong Kong’s financial watchdog is tightening oversight on derivatives markets after the collapse of Archegos Capital Management, a senior official at the city’s Securities and Futures Commission (SFC) said on Tuesday.

Archegos, a U.S.-based family office of investor Bill Hwang which had $36 billion in assets, blew up last year when it was caught short on highly leveraged trades and left global banks with $10 billion in losses.

A majority of Hwang’s exposure was built via a type of equity derivative traded over the counter, written by his bank counterparties, which helped him to circumvent rules requiring reporting positions to U.S. regulators.

“The collapse of Archegos prompted us to take a fresh look at the surveillance tools we use to detect concentrated positions in the over-the-counter (OTC) market,” said SFC Deputy Chief Executive Officer Julia Leung.

Prime brokers operating in the OTC derivatives markets have faced “tough challenges” and it was “evident from the Archegos saga last year,” said Leung, who is also SFC’s executive director for intermediaries.

The regulator clomid sale is also conducting a thematic review of OTC derivatives activities in Hong Kong to assess prevailing market practices, she said, and the scope of the review will probe firms’ risk management, assessment and escalation practices.

Fragmented global practice and regulation in the opaque OTC derivatives market compounds the regulatory challenges, generic clomid no prescription Leung said, adding gaps in oversight would remain unless “risk governance structures” are integrated.

The SFC will also soon launch a review on block trading, or large sales of shares, in Hong Kong with an aim to potentially introduce standards for how to conduct such business activities.

“We are looking into how to get generic clomid market participants communicate information with potential investors prior to the announcement of a (block trade) transaction, commonly known as market sounding,” she added. (Editing by Jacqueline Wong)

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