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Takeda preparing to sell Japan consumer health unit to Blackstone…

TOKYO, Aug 19 (Reuters) – Japan’s Takeda Pharmaceutical Co Ltd is making final arrangements to sell its domestic over-the-counter (OTC) business to U.S. investment fund Blackstone Group Inc, Kyodo News reported on Wednesday.

Takeda, Japan’s largest pharma company, has been reducing its OTC assets worldwide as it seeks to refocus its business and reduce debt following its $59 billion acquisition of Shire.

Blackstone was among final bidders for the OTC unit, Reuters reported in June, along with Bain Capital, CVC Capital Partners and Taisho Pharmaceutical Holdings Co Ltd.

Takeda is looking to sell Takeda Consumer Healthcare, known for cheap clomid pills its Alinamin line of energy drinks, for more than 300 billion yen ($2.85 billion) by the end of the month, Kyodo reported.

A Takeda spokeswoman declined to comment to Reuters on the report beyond saying it had not come from the company. A Blackstone representative was not immediately available for comment.

The Shire acquisition, completed in January 2019, clomid generic expanded Takeda’s drug pipeline and diversified its global sales, but also left it heavily indebted. To reduce the debt, Takeda has pledged to dispose of $10 billion worth of non-core assets.

Takeda’s shares rose 1.1% in Tokyo versus a 0.2% gain for the broader market. ($1 = 105.2600 yen) (Reporting by Chris Gallagher, Rocky Swift and Junko Fujita in Tokyo; Editing by Shri Navaratnam and Christopher Cushing)

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CVS Health raises forecast as insurance business, OTC COVID tests…

Aug 3 (Reuters) – CVS Health Corp on Wednesday raised its full-year profit forecast after strength in its insurance business and sales of COVID-19 over-the-counter test kits helped the company report a 6% jump in second-quarter earnings.

The largest U.S. pharmacy chain’s retail and long-term care segment revenue rose 6.3%, helped by the sale of OTC test kits and the impact of the flu season, which helped offset lower COVID-19 vaccinations and diagnostic testing.

Its insurance business reported an 11% growth in revenue as well as a decrease in medical benefit ratio, get clomid which is the costs it incurs as a percentage of premiums.

CVS raised its adjusted profit outlook to $8.40-$8.60 per share from $8.20-$8.40 per share forecast earlier.

Net income for cheap clomid tablets the quarter ended June 30 rose to $2.96 billion, or $2.23 per share, from $2.79 billion, or $2.10 per share a year earlier. (By Leroy Leo and Bhanvi Satija in Bengaluru; Editing by Vinay Dwivedi)

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FDA proposes rule to make many hearing aids cheaper

November 7, 2023 Loans generic clomid tablets by clemmieroark

Oct 19 (Reuters) – The U.S. Food and Drug Administration on Tuesday proposed creation of a new category of over-the-counter (OTC) hearing aids to be sold directly to millions of Americans in an effort to make the devices more affordable.

White House spokeswoman Jen Psaki said the proposed rules should be finalized next year and should increase competition to drive down prices, so the devices cost of generic clomid no prescription “hundreds instead of thousands of dollars.”

The changes “will help millions of Americans with mild to moderate healing loss get access to cheaper and more convenient access to hearing aids,” she told reporters, adding just one-fifth cost of generic clomid no prescription the estimated 37.5 million Americans who have trouble hearing use such aids.

The rule allows greater reach to communities of color that have been typically lacked access to hearing aids, said Xavier Becerra, secretary cost of generic clomid no prescription Health and Human Services.

Under the proposal, hearing aids for severe hearing loss or for users younger than 18 would remain as prescription devices.

The department will take comments on the proposed rule for 90 days and plan to implement the rule 60 days after finalizing it.

“Finalizing this remains a top priority for the agency,” said Jeff Shuren, director of the FDA’s Center for Devices and Radiological Health, said during a press call.

Representative Debbie Dingell called the announcement “a major step forward for hearing health and will increase the accessibility of affordable hearing aid options for those who need them.”

The proposed rule follows an instruction in President Joe Biden’s broad competition executive order, which had told the Department of Health and Human Services to “promote the wide availability of low-cost of generic clomid no prescription hearing aids,” among many other instructions aimed at a wide variety of industries. (Reporting by Manojna Maddipatla in Bengaluru and Diane Bartz and Trevor Hunnicutt in Washington; Editing by Shinjini Ganguli and Nick Zieminski)

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RAY MASSEY: Lexus joins the big boys with its hybrid RX SUV

November 7, 2023 Loans cheap clomid no prescription by clemmieroark

Amazing to think it’s 30 years since upmarket car brand Lexus was launched by the Japanese car giant Toyota.

Big in Japan and the U.S., Lexus remains a niche player in the UK, targeting discerning drivers who want something a little different.

It’s sold about 200,000 cars here since 1990 and this year is looking at a record 16,000 sales.

Well-padded: The new Lexus RX SUV blends petrol and electric for greater fuel efficiency

So to help celebrate its three decades on the road I’ve been for a spin in the new 5th generation Lexus RX SUV.

Launched in 1998, it has sold 3 million worldwide since then. It’s been a while since I’ve driven a Lexus so I was taken aback by the huge size of the RX.

But it’s taking on big-boned rivals such as the Audi Q7 and Volvo XC90, so size does matter.

LME WEEK-LME looking at fee structure to address cheaper OTC…

November 7, 2023 Loans where to buy cheap clomid by clemmieroark

LONDON, Oct 9 (Reuters) – The London Metal Exchange (LME) is looking at its fee structure where to buy cheap clomid address the fact that over-the-counter (OTC) trading is cheaper than trading on the exchange, the LME’s chief executive said on Monday.

The 146-year-old LME was forced to halt nickel trading and cancel all deals in March last year after a wild spike in prices caused partly by large OTC short nickel positions.

Since then the exchange, the world’s oldest and largest market for industrial metals, has imposed measures requiring members where to buy cheap clomid report all OTC positions.

The LME has said that the market would benefit from more trading migrating to its electronic platform rather than to telephone-based trading or OTC markets.

During a panel discussion on Monday on the future of the LME nickel contract, which saw trading volumes tumble after last year’s crisis, LME CEO Matthew Chamberlain noted that people sometimes ask him why OTC trading is cheaper than on the LME.

“That’s one area we’re looking at,” Chamberlain said, giving no details.

The LME requires institutions that book OTC trades that use LME prices as a benchmark where to buy cheap clomid pay a fee where to buy cheap clomid the LME of $1.14 per equivalent LME lot, which compares to all-in fees of $2.70 per lot paid for exchange trading.

The LME is owned by Hong Kong Exchanges and Clearing Ltd. (Reporting by Eric Onstad; Editing by Sharon Singleton)

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RAY MASSEY: Lexus joins the big boys with its hybrid RX SUV

November 7, 2023 Loans can i order generic clomid by ralf22p01411479

Amazing to think it’s 30 years since upmarket car brand Lexus was launched by the Japanese car giant Toyota.

Big in Japan and can i order generic clomid the U.S., Lexus remains a niche player in the UK, targeting discerning drivers who want something a little different.

It’s sold about 200,000 cars here since 1990 and this year is looking at a record 16,000 sales.

Well-padded: The new Lexus RX SUV blends petrol and electric for greater fuel efficiency

So to help celebrate its three decades on the road I’ve been for a spin in the new 5th generation Lexus RX SUV.

Launched in 1998, it has sold 3 million worldwide since then. It’s been a while since I’ve driven a Lexus so I was taken aback by the huge size of the RX.

But it’s taking on big-boned rivals such as the Audi Q7 and Volvo XC90, so size does matter.

SMALL CAP IDEAS:Diaceutics offers new take on drug development process

November 7, 2023 Loans where can i buy cheap clomid by julietakroeger

Medical advances recently have forced a re-think of the ‘one-drug-fits-all’ approach to therapy.

Something that works for some patients might not work for others or even be dangerous.

Identifying an individual’s biological indicators or biomarkers, therefore, is critical in the precise diagnosis of a patient’s disease and treatment.

It’s known as precision or personalised medicine and helping pharmaceutical companies identify these key genetic traits is the skillset of recent AIM-listee Diaceutics.

Diaceutics is involved in precision medicine testing

In fact, its ticker symbol – DXRX – tells you all you need to know about the business.

DX is the industry abbreviation for testing and RX the shorthand for treatment, and bringing the two together is what the company is all about.

‘Some drugs only work in certain patient types and you find those patients through genetic testing,’ says Peter Keeling, Diaceutics’ chief executive.

To build a dataset, Diaceutics acquires anonymous patient data directly from testing in laboratories, which is then overlaid with information from insurance claims.

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No one dataset ever gives all the answers, says Keeling, and it this layering of information that is the key for its drug developer customers.

The group has been collecting information since it was set up in 2005 and has now amassed a ‘deep data lake’.

That includes 3.5million tests from more than 2,500 laboratories, a US database of 51million patient records, and results from over 53million ‘testing events’ outside the US.

This week, the company added to its database with the acquisition of 16million records for £1million, something it promised when it listed in March.

Data protection rules are strict in both the US and Europe, but the pharma industry itself has a zero tolerance for mistakes in data handling and Diaceutics is keenly aware of its need for security.

The ambition is to be the global market leader in patient test data for a variety of new types cost of generic clomid no prescription precision drugs.

Oncology/cancer testing is a core market for the company alongside multiple sclerosis and rheumatoid arthritis.

Today, precision medicine is all focused on the therapy, but the amount of value in improving patient testing is at least the equivalent to the introduction of a new drug, the company believes.

Industry estimates suggest it can cost of generic clomid no prescription between $1billion -$2billion to develop a new drug and Keeling wants to highlight the value ‘in the first half of the drug development equation’ ie. the testing beforehand.

That means demonstrating just how much money can be released into the healthcare system or to the pharma or clinical groups just by fixing the testing ecosystem. ‘Pharmaceutical groups are good at launching the drugs, but struggle to manage the testing,’ says Keeling.

Oncology/cancer testing is a core market for the company alongside multiple sclerosis and rheumatoid arthritis

It is a growing market. Big pharma already spends around $1billion a year on testing, but Keeling believes this total will double or more over the next 4-5 years. That makes a big target to go for and with the funds available from its listing Diaceutics plans to be in a position to take advantage.

The fact that it is one of only a handful cost of generic clomid no prescription companies to brave the Brexit uncertainty and float this year underlines its confidence. It has been well-rewarded for its endeavour with the share price rising handily since the float.

A placing that preceded the listing and raised £17million at 76p was also heavily over-subscribed. The cash raised was earmarked for patient data acquisitions and to put infrastructure on the ground for a push into Asia and Latin America.

A new software platform, Nexus, that does everything quicker and more efficiently is also under development.

Revenues have grown 40-50 per cent annually over the past five years and brokers expect that the trend of good sales growth will continue helped by the investments made with the placing money.

Sales last year jumped to £10.4million from £7.4million, with profits rising 82 per cent on an underlying basis to £1.9million.

Keeling noted that the business has been profitable from day one, but the group’s listing indicates a step-up in ambition and scale.

The shares now trade at 85.5p each, which values the group at a shade under £60million.

That might look punchy on current yardsticks but if Keeling is right about the direction cost of generic clomid no prescription the pharma industry towards precision medicine testing this is a company that has a lot further to travel.

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As FDA rules some cold drugs don’t work, docs say what to take instead

November 7, 2023 Loans can you buy clomid by julietakroeger

It turns out Grandma may have been right all along: Chicken soup is the perfect remedy for a cold and flu.

Last month, the US Food and Drug Administration (FDA) announced a key ingredient in some of the most common cold medications doesn’t actually work, leaving millions of Americans without reliable cold and flu remedies.

An FDA panel said after a two-day review that phenylephrine, an oral decongestant, ‘is not effective’ at standard or even high doses compared to a placebo and stores began pulling products containing the substance from their shelves, including Benadryl Allergy Plus Congestion, Sudafed PE, and Tylenol Cold and Flu Severe Day & Night.

Dr Stuart Fischer, an internal medicine doctor in New York City, told DailyMail.com there were several over-the-counter alternatives – and natural remedies – that work better.

Dr Fisher’s alternatives to Benadryl Allergy Plus Congestion, Sudafed PE, and Tylenol Cold and Flu Severe Day & Night

CVS will begin pulling popular oral cough and cold products with phenylephrine as the only active ingredient from its store shelves. Pictured: Empty CVS shelves in New York City

The pharmacy chain is removing the products voluntarily after a panel of advisers to the FDA last month refused to back the effectiveness of oral over-the-counter medicines made with the ingredient

Dr Fischer said he was pleased to hear the news and said there are plenty of alternatives that work better than the over-the-counter products, including the age-old recommendation of chicken soup.

Dr Fischer said: ‘I’m not very big on over medicating the signs and symptoms of a winter cold.

‘I see this as our bodies utilizing the immune system and over medicating ourselves so that we feel “normal” – it’s not going to help you.

‘You cannot achieve normal feelings in the midst of a winter virus. It’s going to take time and it’s going to run its course.

‘The idea that someone can totally erase the signs and symptoms of a winter virus – I don’t think that’s necessary and I frankly very rarely recommend [these medications] and I never take them myself.’

In lieu of the products with phenylephrine in them, Dr Fischer recommended other ways to help a person feel better.

When it comes to pharmaceutical options, the physician said taking the regular version of Benadryl that only contains diphenhydramine and not phenylephrine can help people suffering from sinusitis, the swelling of tissue lining the sinuses that causes facial pain and nasal congestion, by drying out of the mucous membranes in the nose.

It can also help ‘dry up’ a wet cough.

The internist also recommended a cough syrup like Robitussin, adding the medication ‘is essentially harmless.’

Dr Fischer said N-acetyl csyteine (NAC), an antioxidant that comes from the amino acid L-cysteine, could help people feeling under the weather.

NAC is thought to possibly play a role in preventing cancer and is used to treat acetaminophen poisoning.

People also commonly use it for a cough and other lung conditions, how to buy clomid as well as the flu and dry eye. There aren’t many studies on NAC and its impact on the immune system, but current research suggests it may help improve immune function.

Phenylephrine is everywhere, so much so that nearly every nasal decongestant on pharmacy shelves contains it

One study found people who took 600 mg of the substance twice a day had fewer flu symptoms than those who took placebo.

A remedy that has been recommended for buying generic clomid no prescription decades, chicken soup, is one of the best things to alleviate the symptoms of a cold or the flu, Dr Fischer said, and he was even taught it during his medical training.

There are three things in chicken soup that are vital to alleviating an illness: the broth, salt and chicken fat.

When people are sick, taking in fluids is essential to stay hydrated, and the broth in soup can help do that.

Secondly, people sick with fevers may be sweating and losing water, but the salt in chicken soup draws water into the body’s cells, rehydrating them.

Lastly, the chicken fat in the soup is a good surfactant, a fat soluble molecule that opens and closes air sacs deep in the lungs, helping people take deep breathes in and breath out more fully.

When it comes to actually preventing illness, one of the best things you can take, according to Dr Fischer, is probiotics.

He said: ‘My own particular way of preventing colds is probiotics. I don’t think anyone can get too many probiotics. I take 25 billion units of probiotics every morning.

‘And this to me is what people mean when they say they have a good immune system. It’s not something inherent in their chemistry, but its live good bacteria overwhelming the bad negative bacteria.’

Probiotics are considered ‘good bacteria’ in the digestive system and can help fight off harmful bacteria that can lead to illnesses.

They can be found in foods like yogurt, cottage cheese and kimchi. Supplements containing different strains are also sold over the counter.

Probiotics have been shown to help boost immune health by balancing the gut’s good bacteria.

Along with the alternative remedies, Dr Fischer stressed people who are sick should rest and take in fluids with electrolytes to replace the fluid they are losing through sweating, which can happen when someone has a fever.

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How airplanes are turned around in less than 35 minutes

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A fascinating video has shed light on how airplanes are turned around in record speed, with everything from refueling to cleaning done in less than 35 minutes.

North Carolina-based travel expert Jeb Brooks and wife Suzanne went behind the scenes while traveling in Europe with Aegean Airlines to show just what happens as planes are flipped for the next load of passengers.

In a YouTube video shot at Thessaloniki, ‘the second largest city in Greece,’ Jeb gets access to the luggage loading area.

He explains, while watching bags on their journey: ‘In this rarely seen part… your bags are making their way through this complex baggage belt system to be loaded onto the plane. Even the way they’re loaded is designed to save time and speed up the process on the other end.’

North Carolina-based travel expert Jeb Brooks and wife Suzanne went behind the scenes while traveling in Europe with Aegean Airlines

Jeb goes into detail around how planes are prepared when he takes a one-hour flight from Thessaloniki to Rhodes

The globetrotter shows how it takes just 35 minutes to turn a plane around on the runway, thanks to a streamlined and well rehearsed process

He points out that the ground handlers working on the runway to prepare the plane are not employed by Aegean Airlines and they are from an external agency called Goldair

Jeb explains that with each flight, the bags are divided between those that will be unloaded at the next destination and those that will go on to connecting flights.

This method, he says, ‘makes it a little faster on the other end’ for the new team of baggage handlers.

Another part of Thessaloniki airport Jeb accessed was a staff briefing room.

He says before each flight, the crew get together for a briefing about the upcoming journey and ‘during this time they’ll discuss the route, weather and anything else particularly unique about the flight including any special requests or needs from passengers.’

Jeb goes into even more detail around how planes are prepared when he takes a one-hour flight from Thessaloniki to Rhodes.

He explains after arriving at his next port of call, that the airport on the Greek island gets busiest during the summer and ‘in the peak days’ they can have ‘as many as 300 aircraft movements a day and something like 12,000 departing passengers.’

The globetrotter then shows how it takes just 35 minutes to turn a plane around on the runway, thanks to a streamlined and well-rehearsed process.

He points out that the ground handlers and the staff working on the runway to prepare the plane are not employed by Aegean Airlines and they are from an external agency called Goldair.

Jeb explains that with each flight, the bags are divided between those that will be unloaded at the next destination and those that will go on to connecting flights

Before each flight, the crew get together for a briefing about the upcoming journey and ‘during this time they’ll discuss the route, weather and anything else particularly unique’

As the timer continues to count down, the ‘pilots complete a safety check, catering gets loaded, the plane takes on fuel and the outbound bags come next’

He says, while watching on from the sidelines in a high visibility jacket: ‘I’m not sure I’ve ever been quite as impressed as I was watching the Goldair team prepare these airplanes for their next trip.

‘It’s truly incredible to see the efficiency with which these ground handlers are unloading this [Airbus] A320neo and getting it ready to head back out.

‘From the moment that your plane pulls up to the gate, Aegean and their partners at Goldair have only 35 minutes to get it going on to its next destination.’

Jeb then runs through each part of the airplane’s turnaround.

He explains: ‘First, stairs are pulled up to the plane and passengers begin disembarking. They’re met by waiting buses.

‘Meanwhile, arriving bags are offloaded, the outbound bags get staged, the plane gets cleaned and trash is removed.’

While the Goldair team continue to work below the wing, 180 passengers begin boarding

In terms of his flight with Aegean Airlines, Jeb seemed thoroughly impressed. He booked business class seats with the perks including more leg room

Jeb’s business class tickets came with free multi-course meals

Next up, as the timer continues to count down, the ‘pilots complete a safety check, catering gets loaded, the plane takes on fuel and the outbound bags come next.’

While the Goldair team continue to work below the wing, 180 passengers begin boarding and once that’s done, ‘the main cabin door is closed the stairs are pulled away and they’re off to Athens.’

After watching the airplane turnaround from start to finish, Jeb praised the impressive production.

‘You’ll be amazed at the symphony that happens before, between and after every flight every single day,’ he concluded.

In terms of his flight with Aegean Airlines, Jeb seemed thoroughly impressed.

He booked business class seats with the perks including an expedited check in, more leg room on the plane, pre-departure beverages in ‘actual glasses,’ and multi-course meals.

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