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People taking blood thinners may risk danger by mixing with OTC meds

November 8, 2023 Loans by

By Reuters Staff

(Reuters Health) – People taking blood-thinning medications often use over-the-counter (OTC) medicines with the potential to cause dangerous internal bleeding, a recent study suggests.

The study focused on 791 patients prescribed apixaban, one of several newer blood thinners known as NOACs (non-vitamin K antagonist oral anticoagulants) that are recommended to prevent stroke in people with atrial fibrillation, a heart rhythm disorder.

Almost all of these patients used over-the-counter medicines, and 33% of them took at least one nonprescription drug daily or most days of the week with the potential to cause dangerous side effects when combined with apixaban. And almost 7% of them regularly took two or more over-the-counter medicines that could be a dangerous mix with apixaban.

“New OTC products are constantly being adopted by patients,” clomid without dr prescription. Derjung Tarn of the David Geffen School of Medicine at UCLA and colleagues write in the Journal of the American Geriatrics Society. “This study demonstrates that patients have limited knowledge about potential serious interactions between OTC products and apixaban.”

In atrial fibrillation, electrical impulses in the upper chambers of the heart are chaotic, causing the heart muscle to quiver rather than contracting normally. As a result, blood doesn’t flow smoothly through the heart. This can lead to the formation of clots that can then travel through the arteries to the brain.

NOACs are the drug of choice for stroke prevention in patients with atrial fibrillation, which occurs most frequently in older patients. Apixaban is one of the most frequently prescribed. Others include dabigatran, rivaroxaban, and edoxaban.

Unlike the older blood-thinner warfarin, which required regular blood tests to prevent side effects, most people prescribed apixaban or other NOACs are not followed in specialized anticoagulation clinics or monthly by health care professionals, the study team writes. As a result, they may not be aware of potential drug interactions.

In the current study, researchers surveyed patients prescribed apixaban in 2018. They asked patients how often they took over-the-counter remedies like aspirin, ibuprofen, naproxen, and acetaminophen. They also asked about common dietary supplements, including Chinese herbs, various fish oils, ginger and herbal teas.

Aspirin was the most commonly used nonprescription treatment in the study, and almost two-thirds of people on aspirin also took at least one other over-the-counter medicine with the potential to increase the risk of bleeding when mixed with apixaban.

The study didn’t look at whether mixing over-the-counter medicines or supplements with blood thinners actually caused bleeding or other dangerous side effects in these patients.

One limitation of the analysis is that researchers relied on patients to accurately recall and report on what over-the-counter medicines and supplements they used.

It’s also not clear from the study whether people started using any of these nonprescription remedies before or after they were prescribed apixaban.

“Patients who have taken OTC medications or dietary supplements clomid without dr prescription any problems prior to starting apixaban may not consider potential interactions, particularly if they ingest the supplements as part of their diet,” the study team writes.

“For example, certain ethnic groups may regularly incorporate dietary supplements, such as turmeric and Chinese herbs, in their meals,” the study team notes. “Unless providers ask them, patients may not realize these are important to disclose.”

SOURCE: website Journal of the American Geriatrics Society, online October 28, 2019.

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FRISCO, Texas (AP) – The Dallas Cowboys and right tackle Terence Steele agreed Sunday on an $86

November 8, 2023 Loans by

FRISCO, Texas (AP) – The Dallas Cowboys and right tackle Terence Steele agreed Sunday on an $86.8 million, five-year extension, a huge payday for an undrafted player coming off an ACL injury.

Steele will get $50 million guaranteed in a contract with a $17 million annual average, which puts the 26-year-old in the top 10 among right tackles. The deal could be worth up to $91.8 million.

ESPN first reported the agreement. The Cowboys signed Steele to a second-round tender at $4.3 million as a restricted free agent after his three-year rookie contract expired.

Steele was cleared for most of training camp despite tearing the ACL in his left knee 13 games into last season.

Undrafted out of Texas Tech, Steele started 14 games as a rookie in 2020 when he replaced an injured La’el Collins. He has started 40 of 45 games.

The deal with Steele comes about three weeks after right guard Zack Martin agreed to a $36.9 million, two-year contract to give the six-time All-Pro a raise and end a camp holdout.

Dallas also signed cornerback Trevon Diggs to $97 million, five-year extension at the start of camp.

___

AP NFL: website offensive tackle Terence Steele agree on $86.8 million…

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Libor demise and Brexit reshape derivatives market, says BIS

November 8, 2023 Loans by

By Huw Jones

LONDON, Oct 27 (Reuters) – Brexit and the demise of Libor are reshaping the world’s over-the-counter (OTC) interest rate derivatives market, where can i buy cheap clomid daily turnover totalled $5.2 trillion in April, down from $6.4 trillion in April 2019, the Bank for International Settlements (BIS) said on Thursday.

“The most significant factor contributing to the decline in turnover is the continuing shift away from Libor for major currencies,” the BIS said in its latest triennial snapshot of the global OTC interest rate derivatives market.

Banks and their clients use interest rate swaps to insure themselves against unexpected moves in borrowing costs.

After banks were fined for trying to rig the London Interbank Offered Rate, or Libor, the bulk of the benchmark’s permutations were scrapped at the end of 2021 and replaced with rates compiled by central banks.

Replacing Libor shrank turnover in forward rate agreements or FRAs, a type of derivatives contract, with turnover in dollar FRAs tumbling by 98%.

Sales desks in Britain recorded the highest turnover of interest rate derivatives, at $2.6 trillion, or 46% of global ‘net-gross’ turnover, down from 51% in 2019.

“Turnover in U.S. dollar swaps has partially shifted from sales desks in the United Kingdom to the United States and Asian financial centres,” the BIS said.

“Similarly, turnover in euro swaps has shifted from the United Kingdom to the euro area.”

Brexit from the end of 2020 meant that EU banks could no longer trade OTC derivatives in London, forcing them to trade on platforms in the United States in some cases.

Turnover in euro contracts reached $1.8 trillion per day in April 2022 to 34% of global turnover, up from 25% in 2019, as dollar contracts fell from roughly half of the global market in 2019 to 44% in April.

Turnover of euro rate swaps in Britain fell 18% to $1 trillion over the three years, while turnover by dealers, particularly in Germany and France more than tripled, from $124 billion in 2019 to $385 billion in 2022.

Euro-denominated contracts, excluding FRAs, traded in euro area countries accounted for clomid more than a quarter of the global total, the highest share since 2010, BIS said.

(Reporting by Huw Jones; Editing by Toby Chopra)

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FDA proposes rule to make many hearing aids cheaper

November 8, 2023 Loans by

Oct 19 (Reuters) – The U.S. Food and Drug Administration on Tuesday proposed creation of a new category of over-the-counter (OTC) hearing aids to be sold directly to millions of Americans in an effort to make the devices more affordable.

White House spokeswoman Jen Psaki said the proposed rules should be finalized next year and should increase competition to drive down prices, so the devices cost “hundreds instead of thousands of dollars.”

The changes “will help millions of Americans with mild to moderate healing loss get access to cheaper and more convenient access to hearing aids,” she told reporters, adding just one-fifth of the estimated 37.5 million Americans who have trouble hearing use such aids.

The rule allows greater reach to communities of color that have been typically lacked access to hearing aids, said Xavier Becerra, secretary of Health and Human Services.

Under the proposal, cheap clomid without rx hearing aids generic clomid for sale severe hearing loss or for users younger than 18 would remain as prescription devices.

The department will take comments on the proposed rule for 90 days and plan to implement the rule 60 days after finalizing it.

“Finalizing this remains a top priority for the agency,” said Jeff Shuren, where to get clomid director of the FDA’s Center for Devices and Radiological Health, said during a press call.

Representative Debbie Dingell called the announcement “a major step forward for hearing health and will increase the accessibility of affordable hearing aid options for those who need them.”

The proposed rule follows an instruction in President Joe Biden’s broad competition executive order, which had told the Department of Health and Human Services to “promote the wide availability of low-cost hearing aids,” among many other instructions aimed at a wide variety of industries. (Reporting by Manojna Maddipatla in Bengaluru and Diane Bartz and Trevor Hunnicutt in Washington; Editing by Shinjini Ganguli and Nick Zieminski)

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Perrigo unit asks FDA to approve first ever OTC birth control pill

November 8, 2023 Loans by

July 11 (Reuters) – Perrigo Company said on Monday its unit HRA Pharma has asked the U.S. Food and Drug Administration (FDA) to approve a daily birth control pill for over-the-counter (OTC) sale, the first such request for this type of contraception.

The application from the HRA comes on the back of the U.S. Supreme Court’s decision in June to overturn the 1973 Roe v. Wade case that legalized abortion nationwide.

The contraceptive is currently a prescription drug sold under brand Opill.

HRA Pharma expects the regulator to hold an advisory committee meeting and approve the application in the first half of 2023, a period of about 10 months is typical for such approval requests, said Frederique Welgryn, HRA Pharma’s chief strategic operations and innovation officer.

“The timing is a bit coincidental. We have been working on that application for the last seven years,” Welgryn said.

The FDA declined to comment on the submission.

Meanwhile, Iffath Abbasi Hoskins, president of the American College of Obstetricians and Gynecologists, said the submission was a positive.

“We know that birth control is not a solution to abortion bans, as people need abortion care for many reasons,” Hoskins said, but added that the pill could still help more people to “control their own reproductive futures”.

Currently, the only contraception drugs available for women without a prescription are emergency oral pills that where can i get clomid no prescription be taken within three days after having unprotected sex.

Abortion rights activists have stepped up calls to make mifepristone, which in combination with misoprostol induces an abortion up to 10 weeks into a pregnancy, available OTC.

The non-estrogen Opill has been used with where can i get clomid no prescription since it was FDA-approved in 1973. Perrigo said scientific evidence has shown progestin-only pills, such as Opill, are effective at preventing pregnancy and safe for most women to use. (Reporting by Leroy Leo in Bengaluru; Editing by Krishna Chandra Eluri and Shinjini Ganguli)

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Hong Kong regulator sharpening scrutiny of derivatives after…

November 8, 2023 Loans by

By Selena Li

HONG KONG, June 28 (Reuters) – Hong Kong’s financial watchdog is tightening oversight on derivatives markets after the collapse of Archegos Capital Management, a senior official at the city’s Securities and Futures Commission (SFC) said on Tuesday.

Archegos, a U.S.-based family office of investor Bill Hwang which had $36 billion in assets, blew up last year when it was caught short on highly leveraged trades and left global banks with $10 billion in losses.

clomid without a prescription majority of Hwang’s exposure was built via clomid without a prescription type of equity derivative traded over the counter, written by his bank counterparties, which helped him to circumvent rules requiring reporting positions to U.S. regulators.

“The collapse of Archegos prompted us to take clomid without a prescription fresh look at the surveillance tools we use to detect concentrated positions in the over-the-counter (OTC) market,” said SFC Deputy Chief Executive Officer Julia Leung.

Prime brokers operating in the OTC derivatives markets have faced “tough challenges” and it was “evident from the Archegos saga last year,” said Leung, who is also SFC’s executive director for intermediaries.

The regulator is also conducting a thematic review of OTC derivatives activities in Hong Kong to assess prevailing market practices, she said, and the scope of the review will probe firms’ risk management, assessment and escalation practices.

Fragmented global practice and regulation in the opaque OTC derivatives market compounds the regulatory challenges, Leung said, adding gaps in oversight would remain unless “risk governance structures” are integrated.

The SFC will also soon launch clomid without a prescription review on block trading, or large sales of shares, in Hong Kong with an aim to potentially introduce standards for how to conduct such business activities.

“We are looking into how market participants communicate information with potential investors prior to the announcement of a (block trade) transaction, commonly known as market sounding,” she added. (Editing by Jacqueline Wong)

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LME starts consultation to make OTC metals market more transparent

November 8, 2023 Loans by

By Zandi Shabalala

LONDON, May 13 (Reuters) – The London Metal Exchange (LME) on Friday proposed measures that it said would improve transparency and how can i get clomid stability in the over-the-counter (OTC) metals market, clomid brand name including more frequent disclosures of all positions.

In March, the exchange was forced to halt trading of nickel after short-covering by one of the world’s top producers, China’s Tsingshan Holding Group, caused prices to skyrocket.

The LME, owned by Hong Kong Exchanges and generic clomid tablets Clearing Ltd , has said Tsingshan’s trades originated primarily in the OTC market.

“Recent events in the LME Nickel market have demonstrated the effects that OTC activity can have on the wider LME market,” the exchange said in a notice announcing a consultation with market participants on its proposals.

“The LME believes it is now essential to accelerate the introduction of regular OTC reporting.”

The OTC market is made up of banks and traders who do deals with one another outside of any exchange.

The LME proposed that its members report weekly to the exchange on all the OTC positions they hold in physically deliverable metals with no minimum position size threshold.

It also proposed that holders of large OTC positions should tell the exchange why they held them.

Previous attempts to introduce transparency to the OTC market were resisted by market participants, the LME said. It said a consultation on its proposals would run until May 27.

In the longer term, clomid order the LME said it was considering imposing real time reporting of OTC trades alongside reporting of OTC positions.

British financial regulators are probing the suspension of the LME’s nickel market.

(Reporting by Zandi Shabalala Editing by Mark Potter)

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Broncos’ Mam set for huge pay rise after GF hat-trick

November 8, 2023 Loans by

Brisbane five-eighth Ezra Mam is set for a multi-million dollar payday after scoring three scintillating tries in his side’s heartbreaking 26-24 NRL grand final loss to Penrith.

The 20-year-old, off contract at the end of 2024, is on a deal worth $250,000 a year but AAP has been told the Broncos intend to upgrade and extend him before November 1 to ensure Mam stays at the club long-term.

Steve Renouf, the only other Broncos player to have scored a hat-trick in a grand final – in the 1997 Super League title win over Cronulla – said Mam belonged at the Broncos.

“Ezra is our future in the halves. I’m sure the Broncos will keep him. To score three tries in a grand final was just incredible,” Renouf told AAP.

“The way he burned their fullback (Dylan Edwards) with speed just doesn’t happen.

“He’s so quick and such a tough footballer, the little man.”

Renouf was just as devastated as the players after the Broncos gave up a 24-8 lead to lose in the season finale.

“It is a different feeling when you (score three tries and) win but you could see how gutted Ezra was,” Renouf said.

“He loves the Broncos. We are all hurting but the boys will be back. There’s a great future ahead of them.”

Mam was crestfallen in the dressing sheds but held his head high.

His third try, off a Reece Walsh bust, was something to savour after he’d blitzed the Panthers twice with lightning speed

“It was definitely a moment in the game I was proud of. It didn’t mean much because we didn’t get the win. Full credit to Penrith for showing class,” Mam said on Sunday night.

“When I am on the footy field I feel free and being able to play with the boys we had tonight was a dream come true.

“We just couldn’t get the fairytale end.

“We got a bit too complacent. You can’t really do that against players like Nathan Cleary. We will take a lesson out of tonight.

“(After missing the finals) last year we took that hurt and turned it around this year and got to the GF. We will let this hurt us and be back next year.”

Club legend Darren Lockyer, the last Bronco to win a title wearing the No.6, was in awe of Mam’s performance.

“It was amazing,” 2006 champion Lockyer said.

“To score a hat-trick in a grand final and lose; when was the last time that happened?

“He probably had the (Clive Churchill) medal around his neck until the last five minutes.”

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Emergent aims to price over-the-counter Narcan at about $50

November 8, 2023 Loans by

April 20 (Reuters) – Contract drugmaker Emergent BioSolutions Inc said on Thursday it is aiming to price the over-the-counter (OTC) version of its opioid overdose reversal drug Narcan at around $50 per carton.

The OTC version will become available at U.S. stores and online retailers later this summer, while the currently available prescription nasal spray carries a wholesale price tag of $125 per carton.

Emergent’s statement comes nearly a month after the U.S. Food and Drug Administration allowed Narcan to be sold over-the-counter, allowing for easier availability of the life-saving medication.

The approval paved the way for expanded access to the drug in areas that have concentrated overdose problems and a few pharmacies, but uncertainty remains around Narcan’s final price and whether insurers will offer coverage.

Emergent has not disclosed the final price for OTC Narcan yet.

“A goal for the out-of-pocket retailer price is to be consistent with our public interest pricing for one carton of two 4 milligram doses,” the company said in its statement, adding that current price for public interest groups averages less than $50.

Customers will pay the out-of-pocket retailer price, which is set by individual retailers for Narcan once it becomes available in the United States.

Prescription Narcan is currently covered under commercial- and government-backed insurance plans, which allows people to can you get generic clomid the drug for free from the pharmacy or for a nominal co-pay.

Government-backed Medicare health insurance plans do not cover OTC products, but have previously made exceptions such as in the case of COVID-19 tests.

Naloxone-based Narcan rapidly reverses or blocks the effects of opioids, restoring normal respiration, especially when given within minutes of the first signs of an overdose.

(Reporting by Bhanvi Satija in Bengaluru; Editing by Devika Syamnath)

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Health Canada says more heartburn medicines being recalled after…

November 8, 2023 Loans by

Sept 25 (Reuters) – Health Canada said on Wednesday four companies were recalling popular heartburn drug ranitidine, known by its brand name Zantac, after presence of a probable cancer-causing impurity was found in some of the drugs.

The companies recalling the drugs include Apotex Inc, Pro Doc Limitée, Sanis Health Inc and Sivem Pharmaceuticals ULC, along with Novartis AG’s recall, which was announced last week.

Branded versions of the drug such as Sanofi SA’s Zantac are available for over-the-counter (OTC) sale in Canada, while generic versions are available for sale both OTC and with prescription. (Reporting by Manas Mishra in Bengaluru; Editing by Shounak Dasgupta)

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