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Takeda preparing to sell Japan consumer health unit to Blackstone…

TOKYO, Aug 19 (Reuters) – Japan’s Takeda Pharmaceutical Co Ltd is making final arrangements to sell its domestic over-the-counter (OTC) business to U.S. investment fund Blackstone Group Inc, Kyodo News reported on Wednesday.

Takeda, Japan’s largest pharma company, has been reducing its OTC assets worldwide as it seeks to refocus its business and reduce debt following its $59 billion acquisition of Shire.

Blackstone was among final bidders for the OTC unit, Reuters reported in June, along with Bain Capital, CVC Capital Partners and Taisho Pharmaceutical Holdings Co Ltd.

Takeda is looking to sell Takeda Consumer Healthcare, known for its Alinamin line of energy drinks, for more than 300 billion yen ($2.85 billion) by the end of the month, can i order cheap clomid Kyodo reported.

A Takeda spokeswoman declined to comment to Reuters on the report beyond saying it had not come from the company. A Blackstone representative was not immediately available for comment.

The Shire acquisition, completed in January 2019, expanded Takeda’s drug pipeline and diversified its global sales, but also left it heavily indebted. To reduce the debt, Takeda has pledged to dispose of $10 billion worth of non-core assets.

Takeda’s shares rose 1.1% in Tokyo versus a 0.2% gain for cheap clomid without rx the broader market. ($1 = 105.2600 yen) (Reporting by Chris Gallagher, Rocky Swift and Junko Fujita in Tokyo; Editing by Shri Navaratnam and Christopher Cushing)

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Emergent aims to price over-the-counter Narcan at about $50

April 20 (Reuters) – Contract drugmaker Emergent BioSolutions Inc said on Thursday it is aiming to price the over-the-counter (OTC) version of its opioid overdose reversal drug Narcan at around $50 per carton.

The OTC version will become available at U.S. stores and online retailers later this summer, while the currently available prescription nasal spray carries a wholesale price tag of $125 per carton.

Emergent’s statement comes nearly a month after the U.S. Food and Drug Administration allowed Narcan to be sold over-the-counter, allowing for easier availability of the life-saving medication.

The approval paved the way for expanded access to the drug in areas that have concentrated overdose problems and a few pharmacies, but uncertainty remains around Narcan’s final price and whether insurers will offer coverage.

Emergent has not disclosed the final price for OTC Narcan yet.

“A goal for the out-of-pocket retailer price is to be consistent with our public interest pricing for one carton of two 4 milligram doses,” the company said in its statement, adding that current price for public interest groups averages less than $50.

Customers will pay the out-of-pocket retailer price, which is set by individual retailers for Narcan once it becomes available in the United States.

Prescription Narcan is currently covered under commercial- and government-backed insurance plans, which allows people to how can i get clomid the drug for free from the pharmacy or for a nominal co-pay.

Government-backed Medicare health insurance plans do not cover OTC products, but have previously made exceptions such as in the case of COVID-19 tests.

Naloxone-based Narcan rapidly reverses or blocks the effects of opioids, generic clomid online restoring normal respiration, especially when given within minutes of the first signs of an overdose.

(Reporting by Bhanvi Satija in Bengaluru; Editing by Devika Syamnath)

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FDA may approve birth control pill WITHOUT prescription by summer

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Come this summer, women could have access to birth control pills without a prescription for the first time in US history.

The Food and Drug Administration is weighing the merits of approving a type of over-the-counter birth control in use since the 1970s called Opill, a progestin-only clomid pill that prevents unwanted pregnancies in about 94 percent of cases.

HRA Pharma presented real-world evidence Tuesday that showed the vast majority of eligible people took its pill correctly without negative consequences and followed the instructions without the help of a medical professional, a concern that FDA officers had about making it OTC.

The manufacturer of the FDA-approved prescription drug also reported that teenagers and people with less understanding of their health and the healthcare system were able to stick to their daily medication regimen, a strong sign that the populations most vulnerable to unplanned pregnancies would be well protected.

The debate about prescription-free birth control has been brewing for years but hit a boiling point last year following the groundbreaking decision by the Supreme Court to rescind the federal guarantee to abortion established 50 years ago.

HRA Pharma, the now owned by Perrigo approval for the first-ever birth control pill that women could buy without a prescription. The request from a French drugmaker sets up a high-stakes decision for the Food and Drug Administration amid the political fallout from the Supreme Court’s recent decision overturning Roe v Wade

Access to mifepristone, one of two pills in a medication abortion regimen, has become a fixture of the culture wars dictated by far-right conservative ideology.

While birth control is entirely and completely different from mifepristone, it has been swept up in the fight over abortion since Supreme Court Justice wrote that the court ‘should reconsider’ several precedents that concern the right to privacy—including the legality of contraception.

Approving Opill for use over the counter would widen birth control options for more than 19 million women living in areas of the US without reasonable access to a health center that offers the full range of contraceptive methods.

Roughly three dozen medical organizations including the American Medical Association, the American College of Obstetricians and Gynecologists (ACOG), and the American Academy of Family Physicians have been calling for a non-prescription birth control clomid pill option for years.

Opill, also called the mini-clomid pill, has been safely in use for about five decades, but the US is an outlier when it comes to making the pills available without a doctor’s order.

Opill contains progestin only, unlike many oral contraceptives that contain both progestin and estrogen.

This is the appeal of the mini-clomid pill. Because it does not contain estrogen, which increases the risk of blood clotting by several-fold, the progestin-only pills is seen as lower-risk.

Its modus operandi is to thicken mucus in the cervix, making it difficult for sperm to enter the uterus and fertilize an egg.

Progestin-only pills do not prevent ovulation as well as combination birth control pills. Therefore, their effectiveness is slightly lower.

The FDA’s Nonprescription Drugs Advisory Committee and the Reproductive and Urologic Drugs Advisory Committee had two primary concerns about designating Opill for over the counter use.

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U.S. FDA staff flag no new safety concerns for OTC opioid overdose…

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By Bhanvi Satija

Feb 13 (Reuters) – The U.S. Food and Drug Administration’s staff reviewers on Monday did not flag any new safety concerns related to Emergent BioSolutions Inc’s over-the-counter version of nasal spray Narcan for reversing opioid overdose.

The FDA’s advisory panel will meet on Wednesday to discuss the first OTC version of Narcan, or naloxone, used to prevent death by overdose.

One advantage of switching to OTC could be reducing the chance of mistakenly using it for other conditions, the reviewers said.

“For the nonprescription product, patients will have to select the product for the suspected or known opioid overdose off the shelf,” said staff reviewers in briefing documents published on the agency’s website.

Some experts were optimistic that a favorable vote from the committee could make an impact on the overdose crisis.

“It’s not sufficient, but it is a piece of the puzzle we need to put in place,” said Maryann Mason, Associate Professor at Northwestern University’s Feinberg School of Medicine.

The panel is expected to weigh in on how to improve labeling of Emergent’s Narcan to ensure safe and effective use by a consumer in an emergency situation.

“Labeling with an idea to limited literacy is a good idea. So it will be important to make pictorials and other aides available,” added Mason.

FDA approval for where buy cheap clomid OTC Narcan could increase its availability and would align the federal government’s stance with that of various states that have provisions to offer Narcan or naloxone without prescriptions through a pharmacist.

However, some doctors cautioned against prescription-free use of naloxone, which rapidly reverses or buying generic clomid blocks the effects of opioids, citing the need for professional oversight.

“It must be given just by professional people as patients might need medical supervision immediately after,” said Dr. Andre Waismann, founder of Accelerated Neuro-Regulation Clinics. (Reporting by Bhanvi Satija and Pratik Jain in Bengaluru; Editing by Dhanya Ann Thoppil, Devika Syamnath and Krishna Chandra Eluri)

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Japan’s Takeda eyes new focus on vaccines after OTC asset sales-CEO

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By Rocky Swift

TOKYO, Nov 6 (Reuters) – Japan’s Takeda Pharmaceutical Co is looking at making vaccines a core business after completing asset sales to lower debt following its takeover of Shire Plc, Chief Executive Christophe Weber said.

Japan’s biggest drugmaker by revenue recently completed $10 billion in sales of mostly over-the-counter drug assets to reduce debt after its $59 billion purchase of Shire, saying it would focus on five key business areas.

With a dengue fever vaccine in development and deals to make and distribute COVID-19 vaccines in Japan, the company could add a new pillar to its business lineup, Weber said.

“We are in the vaccines business,” Weber told Reuters in an interview. “If the dengue vaccine is successful, yes, it would be a sixth one.”

Takeda’s current five core businesses are oncology, gastroenterology, neuroscience, rare diseases, and plasma-derived therapies.

The company looked into making a COVID-19 vaccine, but determined with its mix of technology and capacity, it was a better fit to work with other developers, Weber said.

Takeda agreed last month to distribute 50 million doses of Moderna Inc’s COVID-19 vaccine in Japan. That was on top of a previous deal where to buy clomid produce Novavax Inc’s COVID-19 candidate, aiming to make 250 million doses.

Takeda’s dengue vaccine candidate, TAK-003, is on track for regulatory filing in Asia, Latin America, and the European Union by the end of fiscal 2020, the company said last month. The disease is spread by mosquitoes and is estimated to affect 50 million people a year worldwide with 22,000 deaths.

Following the Shire takeover, Takeda reached its asset disposal goal with the sale of its Japanese consumer healthcare business to Blackstone Group for 242 billion yen ($2.31 billion) announced in August.

The company was not eyeing any more major sell offs, Weber said, saying any such deals would be “very marginal.” (Reporting by Rocky Swift; editing by Jane Wardell)

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RAY MASSEY: Lexus joins the big boys with its hybrid RX SUV

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Amazing to think it’s 30 years since upmarket car brand Lexus was launched by the Japanese car giant Toyota.

Big in Japan and the U.S., Lexus remains a niche player in the UK, targeting discerning drivers who want something a little different.

It’s sold about 200,000 cars here since 1990 and this year is looking at a record 16,000 sales.

Well-padded: clomid pills The new Lexus RX SUV blends petrol and electric for greater fuel efficiency

So to help celebrate its three decades on the road I’ve been for a spin in the new 5th generation Lexus RX SUV.

Launched in 1998, it has sold 3 million worldwide since then. It’s been a while since I’ve driven a Lexus so I was taken aback by the huge size of the RX.

But it’s taking on big-boned rivals such as the Audi Q7 and Volvo XC90, so size does matter.

McKesson to buy pharma tech firm Rx Savings for up to $875 mln

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Sept 19 (Reuters) – Drug distributor can you get generic clomid McKesson Corporation said on Monday it would acquire private pharma technology firm Rx Savings Solutions for up to $875 million.

The company helps health insurers and employers seek lower cost prescription medicines, and also provides ongoing medication reminders to help improve adherence to prescriptions.

“Rx Savings Solutions´ offerings for employers and patients will strengthen McKesson´s ability to help solve the most common medication challenges related to access, affordability and adherence,” McKesson Chief Executive Officer Brian Tyler said.

The transaction, generic clomid tablets which includes a $600 million upfront payment and buy clomid up to $275 million contingent on Rx Savings’ financial performance through 2025, is expected to close in the second half of fiscal year 2023. (Reporting by Leroy Leo and can you get cheap clomid without prescription Khushi Mandowara in Bengaluru; Editing by Vinay Dwivedi)

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