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Sept 25 (Reuters) – Health Canada said on Wednesday four companies were recalling popular heartburn drug ranitidine, known by its brand name Zantac, after presence of a probable cancer-causing impurity was found in some of the drugs.
The companies recalling the drugs include Apotex Inc, Pro Doc Limitée, Sanis Health Inc and Sivem Pharmaceuticals ULC, along with Novartis AG’s recall, how to get clomid which was announced last week.
Branded versions of the drug such as Sanofi SA’s Zantac are available for over-the-counter (OTC) sale in Canada, while generic versions are available for sale both OTC and with prescription. (Reporting by Manas Mishra in Bengaluru; Editing by Shounak Dasgupta)
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By Pratima Desai
LONDON, June 17 (Reuters) – The London Metal Exchange (LME) approved rules on Friday for members to report all over the counter (OTC) positions, a move taken after off-exchange trading was partly blamed for a wild spike in nickel prices in March.
“This … will improve the ability of the LME to oversee activity holistically through increased visibility, ensuring future market stability,” the exchange said in a statement.
The exchange, owned by Hong Kong Exchanges and Clearing Ltd , was forced to suspend nickel trading and cancel all deals on March 8 because of disorderly activity caused partly by a large OTC short nickel position.
The new rules, clomid cheap due to take effect in one month, require OTC positions reported on a weekly basis in all physically-delivered metals including aluminium, copper and nickel.
The LME has withdrawn an existing requirement for members to report daily their OTC nickel positions.
The LME, cost clomid the world’s oldest and largest market for industrial metals, will also require holders of large OTC positions to tell the exchange the rationale for holding them.
The LME received 27 submissions during its two-week consultation period, with a majority opposed to introducing the OTC rules before probes were completed into what caused chaotic nickel trading in March.
Benchmark nickel on the LME doubled to a record above $100,000 a tonne on March 8 on expectations China’s Tsingshan Holding Group and others would have to buy back their short positions, which bets on prices falling.
British financial regulators in April launched a sweeping probe into how the LME suspended nickel trading and the LME also commissioned its own independent review.
“While any relevant findings from the independent review will also be considered and factored into the LME´s plans in due course, the LME will not delay taking appropriate actions,” it said.
U.S. hedge fund Elliott Associates and Jane Street Global Trading are suing the LME for $456 million and $15.3 million respectively for cancelled nickel trades. (Additional reporting by Eric Onstad; Editing by Edmund Blair)
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April 4 (Reuters) – The London Metal Exchange said on Monday it would commission an independent review into the events that led to chaos in the nickel market last month, and said it had introduced daily price limits for all its metals.
The LME, the world’s oldest and largest market for industrial metals, last month brought in 15% upper and lower daily price limits for all of its physically delivered metals plus cash-settled cobalt.
The exchange suspended nickel trading on March 8 after prices spiked by more than 50% to hit $100,000 a tonne. Activity resumed on March 16 when it launched daily price limits and the provision of OTC nickel trading data for the first time.
The price surge was blamed on short-covering by one of the world’s top nickel producers, China’s Tsingshan Holding Group. The LME has said the large short positions originated primarily from the over-the-counter (OTC) market.
The exchange also said it wanted to introduce OTC trade reporting across the board and that a first step was to extend provision of OTC daily position reporting, as is now implemented for nickel, to other metals.
The LME said it welcomed an announcement by British financial regulators who said on Monday that they would review the way the exchange handled the halt in nickel trading last month.
It added that it would also commission an independent review of events leading up where to get cheap clomid the trading suspension in an attempt to prevent a repeat of such a situation. (Reporting by Swati Verma in Bengaluru; Editing by David Goodman,Pravin Char and David Evans)
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Medical advances recently have forced a re-think of the ‘one-drug-fits-all’ approach to therapy.
Something that works for some patients might not work for others or even be dangerous.
Identifying an individual’s biological indicators or biomarkers, therefore, is critical in the precise diagnosis of a patient’s disease and treatment.
It’s known as precision or personalised medicine and helping pharmaceutical companies identify these key genetic traits is the skillset of recent AIM-listee Diaceutics.
Diaceutics is involved in precision medicine testing
In fact, its ticker symbol – DXRX – tells you all you need to know about the business.
DX is the industry abbreviation for testing and RX the shorthand for treatment, and bringing the two together is what the company is all about.
‘Some drugs only work in certain patient types and you find those patients through genetic testing,’ says Peter Keeling, Diaceutics’ chief executive.
To build a dataset, Diaceutics acquires anonymous patient data directly from testing in laboratories, which is then overlaid with information from insurance claims.
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clomid no prescription one dataset ever gives all the answers, says Keeling, and it this layering of information that is the key for its drug developer customers.
The group has been collecting information since it was set up in 2005 and has now amassed a ‘deep data lake’.
That includes 3.5million tests from more than 2,500 laboratories, a US database of 51million patient records, and results from over 53million ‘testing events’ outside the US.
This week, the company added to its database with the acquisition of 16million records for £1million, something it promised when it listed in March.
Data protection rules are strict in both the US and Europe, but the pharma industry itself has a zero tolerance for mistakes in data handling and Diaceutics is keenly aware of its need for security.
The ambition is to be the global market leader in patient test data for a variety of new types of precision drugs.
Oncology/cancer testing is a core market for the company alongside multiple sclerosis and rheumatoid arthritis.
Today, precision medicine is all focused on the therapy, but the amount of value in improving patient testing is at least the equivalent to the introduction of a new drug, the company believes.
Industry estimates suggest it can cost between $1billion -$2billion to develop a new drug and Keeling wants to highlight the value ‘in the first half of the drug development equation’ ie. the testing beforehand.
That means demonstrating just how much money can be released into the healthcare system or to the pharma or clinical groups just by fixing the testing ecosystem. ‘Pharmaceutical groups are good at launching the drugs, but struggle to manage the testing,’ says Keeling.
Oncology/cancer testing is a core market for the company alongside multiple sclerosis and rheumatoid arthritis
It is a growing market. Big pharma already spends around $1billion a year on testing, but Keeling believes this total will double or more over the next 4-5 years. That makes a big target to go for and with the funds available from its listing Diaceutics plans to be in a position to take advantage.
The fact that it is one of only a handful of companies to brave the Brexit uncertainty and float this year underlines its confidence. It has been well-rewarded for its endeavour with the share price rising handily since the float.
A placing that preceded the listing and raised £17million at 76p was also heavily over-subscribed. The cash raised was earmarked for patient data acquisitions and to put infrastructure on the ground for a push into Asia and Latin America.
A new software platform, Nexus, that does everything quicker and more efficiently is also under development.
Revenues have grown 40-50 per cent annually over the past five years and brokers expect that the trend of good sales growth will continue helped by the investments made with the placing money.
Sales last year jumped to £10.4million from £7.4million, with profits rising 82 per cent on an underlying basis to £1.9million.
Keeling noted that the business has been profitable from day one, but the group’s listing indicates a step-up in ambition and scale.
The shares now trade at 85.5p each, which values the group at a shade under £60million.
That might look punchy on current yardsticks but if Keeling is right about the direction of the pharma industry towards precision medicine testing this is a company that has a lot further to travel.
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By Pratima Desai
LONDON, June 17 (Reuters) – The London Metal Exchange (LME) approved rules on Friday for members to report all over the counter (OTC) positions, a move taken after off-exchange trading was partly blamed for a wild spike in nickel prices in March.
“This … will improve the ability of the LME to oversee activity holistically through increased visibility, ensuring future market stability,” the exchange said in a statement.
The exchange, owned by Hong Kong Exchanges and Clearing Ltd , was forced how to get cheap clomid suspend nickel trading and cancel all deals on March 8 because of disorderly activity caused partly by a large OTC short nickel position.
The new rules, due to take effect in one month, require OTC positions reported on a weekly basis in all physically-delivered metals including aluminium, copper and nickel.
The LME has withdrawn an existing requirement for members to report daily their OTC nickel positions.
The LME, the world’s oldest and largest market for industrial metals, will also require holders of large OTC positions to tell the exchange the rationale for holding them.
The LME received 27 submissions during its two-week consultation period, with a majority opposed to introducing the OTC rules before probes were completed into what caused chaotic nickel trading in March.
Benchmark nickel on the LME doubled how to get cheap clomid a record above $100,000 a tonne on March 8 on expectations China’s Tsingshan Holding Group and others would have how to get cheap clomid buy back their short positions, which bets on prices falling.
British financial regulators in April launched a sweeping probe into how to get cheap clomid the LME suspended nickel trading and the LME also commissioned its own independent review.
“While any relevant findings from the independent review will also be considered and factored into the LME´s plans in due course, the LME will not delay taking appropriate actions,” it said.
U.S. hedge fund Elliott Associates and Jane Street Global Trading are suing the LME for $456 million and $15.3 million respectively for cancelled nickel trades. (Additional reporting by Eric Onstad; Editing by Edmund Blair)
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By Nimesh Vora
MUMBAI, Sept 28 (Reuters) – The imminent expiry of the USD/INR monthly futures contract has led to higher demand for dollars in the over-the-counter (OTC) market, traders said on Wednesday.
The NSE September futures contract is set to expire at noon.
Banks, who had build positions in OTC and in futures to take advantage of arbitrage opportunities, were offering a premium to buy cheap clomid dollars at the Reserve Bank of India reference rate.
The futures leg of the contract expires automatically at the RBI reference rate, but the OTC leg needs to closed by buying or selling dollars.
The premium that traders were willing to pay to buy cheap clomid dollars at the Reserve Bank of India reference rate, rose to as much as 0.04 rupees, compared to almost par or 0.01 in recent weeks, a trader at a private sector bank said.
This means that if the RBI reference rate was fixed at 81.88 on Wednesday, the actual transaction price will be 81.92.
“There is demand from foreign banks for buying (dollars) at the fixing rate, probably related to offshore (clients),” the trader said.
“The squaring of futures-OTC arbitrage position is one more reason for the demand.”
The open interest on the contract was at around $2.2 billion, down about $150 million from the previous session.
Meanwhile, the Indian rupee dropped to a record low of 81.9350, down from 81.58 in the previous session.
The RBI likely sold dollars via state-run banks to slow the pace of rupee’s fall, traders said. (Reporting by Nimesh Vora; Editing by Neha Arora)
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FRANKFURT, cheap clomid without prescription Sept 13 (Reuters) – The EEX Group said on Tuesday is had launched a new trade registration platform called Touchpoint to ease the process of registering over-the-counter (OTC) trades across all EEX markets.
The EEX, Europe’s leading electricity bourse that has branched out into more regions and products, said Touchpoint would allow brokers, trading and clearing members using the bourse to register OTC trading on behalf of customers more easily.
In Europe’s wholesale energy market, OTC trades for spot and long-term positions still dominate volumes, but regulated marketplaces such as EEX are gaining more traction as they offer price transparency and integrated clearing.
The new tool comes as energy markets are seeing significant price volatility on concerns that Russia will curb gas flows to Europe further, while suffering from technical and weather-related issues at French nuclear plants and drought affecting coal deliveries.
As a consequence of the volatile market environment, trade margins that must be deposited with its clearing house ECC have increased significantly, which poses financial challenges and has thinned turnover.
Chief Operating Officer Steffen Koehler said Touchpoint would help customers to better navigate the difficult times because it included risk management and analysis functions to track their OTC workflows.
EEX counts 800 trading participants in asset classes including power, gas, emissions, dry freight and agriculture. (Reporting by Vera Eckert, can i get generic clomid editing by David Evans)
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By Bhanvi Satija
Feb 13 (Reuters) – The U.S. Food and Drug Administration’s staff reviewers on Monday did not flag any new safety concerns related to Emergent BioSolutions Inc’s over-the-counter version of nasal spray Narcan for reversing opioid overdose.
The FDA’s advisory panel will meet on Wednesday to discuss the first OTC version of Narcan, or naloxone, used to prevent death by overdose.
One advantage of switching to OTC could be reducing the chance of mistakenly using it for other conditions, the reviewers said.
“For the nonprescription product, patients will have to select the product for the suspected or known opioid overdose off the shelf,” said staff reviewers in briefing documents published on the agency’s website.
Some experts were optimistic that a favorable vote from the committee could make an impact on the overdose crisis.
“It’s not sufficient, but it is generic clomid without a prescription piece of the puzzle we need to put in place,” said Maryann Mason, Associate Professor at Northwestern University’s Feinberg School of Medicine.
The panel is expected to weigh in on how to improve labeling of Emergent’s Narcan to ensure safe and effective use by a consumer in an emergency situation.
“Labeling with an idea to limited literacy is generic clomid without a prescription good idea. So it will be important to make pictorials and other aides available,” added Mason.
FDA approval for OTC Narcan could increase its availability and would align the federal government’s stance with that of various states that have provisions to offer Narcan or naloxone generic clomid without a prescription prescriptions through generic clomid without a prescription pharmacist.
However, some doctors cautioned against prescription-free use of naloxone, which rapidly reverses or blocks the effects of opioids, citing the need for professional oversight.
“It must be given just by professional people as patients might need medical supervision immediately after,” said Dr. Andre Waismann, founder of Accelerated Neuro-Regulation Clinics. (Reporting by Bhanvi Satija and Pratik Jain in Bengaluru; Editing by Dhanya Ann Thoppil, Devika Syamnath and Krishna Chandra Eluri)
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