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crack[The state of the hypothalamo-hypophyseal-adrenal system in the acute experimental head injury].
Examinations of the hypothalamo-hypophyseal-adrenocortical system in rats under acute experimental craniocerebral injury revealed that a rise in the content of dehydroepiandrosterone in the blood plasma is the result of activation of the function of this system rather than of a traumatic effect. A rise in the concentration of the above hormone in the blood plasma is a morphological and biochemical correlate of its active synthesis in the adrenal cortex. A latent period for the initiation of adaptive-compensatory changes in the hypothalamo-hypophyseal-adrenocortical system runs from 3 to 30 hrs, depending on a severity of traumatic factors.Eosinophilic esophagitis: correlation between clinical symptoms and quality of life.
The present study examines the relationship between eosinophilic esophagitis (EoE), dysphagia, dyspepsia, and quality of life in a group of patients with EoE and controls. Thirty-eight patients were enrolled in this study and had esophagoscopy and questionnaire for measuring quality of life (SF-36) and esophageal function (Eckl and Redzyn). Eosinophilic esophagitis is characterized by eosinophilic infiltration of the esophagus. To evaluate this disease, esophagoscopy and questionnaires were used. The questionnaires included the Gastrointestinal Quality of Life Index (GIQLI), the Dysphagia Handicap Index (DHI), and the Trimbos/iMTA questionnaire for specific health problems (TQ). Two hundred and eleven healthy volunteers were studied as control group. Eosinophilic esophagitis patients had significant lower scores in the GIQLI, DHI, and TQ. Symptoms of dysphagia were highly prevalent and correlated with the GIQLI (R2 = 0.24) and DHI (R2 = 0.22). Dyspepsia was also highly prevalent in EoE patients and was significantly correlated with the GIQLI (R2 = 0.29), DHI (R2 = 0.25), and the TQ (R2 = 0.22). These results confirm a close relationship between EoE and dysphagia, dyspepsia
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