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pixiv on minijupe.metropass A ver a pixiv de pequeños tiburones y otras cosas gratis. Descargar Gratis PIXIV CLUB DE PEQUEÃOS TURISTAS.The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of natural products isolated from Streptomyces, e.g., S. niveus and various fermentation broths. ##STR2##
The PBDs were first discovered as antibiotics produced by various strains of Streptomyces. PBDs were first reported in 1962 by Bar-Joseph et al. (Nature 190:1009 (1962)) and in 1969 by Cole et al. (J. Antibiotics 22:207 (1969)) who described the antibiotic activity of this class of compounds.
Subsequently, PBDs with a range of biological and pharmacological properties have been reported. Thus, they are potent and specific inhibitors of the cell wall synthesis in a number of organisms including gram positive and gram negative bacteria (Hermanowicz-Robak et al., FEMS Microbiology Reviews, 7: p. 201-225 (1993), Heteronuclear antibiotics from Streptomyces sp. H64300 (Murphy et al., J. Antibiotics 47:344 (1994)). The first synthetic PBDs were reported by Price et al. (J. Am. Chem. Soc. 109:1214 (1987)). Since then, several hundred PBDs have been synthesized and reported in the literature (see, e.g., U.S. Pat. No. 4,618,669 for a general description).
PBDs have also been developed into drugs for the treatment of infectious diseases. For example, U.S. Pat. No. 5,688,792 describes their use for treating bacterial infections. Because of their activity against gram positive and gram negative bacteria, PBDs are also useful for treating venous ulcers, for example, U.S. Pat. No. 6,054,590.
PBDs are also known to be useful in photodynamic therapy (PDT) as sensitizers. For example, U.S. Pat. No. 6,444,444 discloses that certain pyrrolo[2,1-c][1,4]benzod
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