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In this new series, we will focus on the monochromatic view of the ancient world in a different way than ever before, bringing to life the exotic lands of the Levant, the Mediterranean and Persia/Iran.
It is also a very regular occurrence in the field of archaeology that our understanding of the Ancient world is evolving and changing, even as we search for new ways of looking at the past.
We are excited to begin sharing the fruits of a year long faculty-led research project which explores the debates surrounding the definition of Levantine antiquity, and tries to explore a new way of understanding the region through a combination of images and words. The project is based on a corpus of data assembled over the past 5 years.
We present an online documentary of the project and its findings and invite the reader to join the discussion. We present our study in three distinct series. We hope that this series will continue to grow as we touch upon different aspects of the Ancient world we love and study.
**WARNING: THE FEATURES PRESENT IN THIS WEBSITE MAY CONTAIN IMAGES THAT ARE NOT PROTECTED BY COPYRIGHT.18 May 2011
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Development of a keratinocyte-specific microgel-based wound dressing with the ability of wound exudate retention, thereby enhancing the wound healing process. To this end, a microgel of chitosan, glycerin and heparin was developed. Specifically, 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide and N-hydroxysuccinimide were used to conjugate chitosan (CTSC) and heparin (HP) to glycerin (GL), forming polymeric microgel (CTSC-HP-GL) in water. The effect of the microgel on the properties of the dressing was examined by using Fourier-transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry. The non-leaching property of the microgel was also analyzed to ensure its safety profile on skin under the in vivo condition. Additionally, the biocompatibility and cell adherence efficiency of CTSC-HP-GL to mouse fibroblast and human keratinocyte cells were examined using colony formation and in vitro wound scratch assays, respectively. The in vivo adherence, acute inflammation, and granulation effects were tested in a mouse wound model. The CTSC-HP-GL microgel showed nanosized crystalline and amorphous structures with significant improvements in their thermal properties compared to the raw GL. Moreover, the glucosamine (-NH2) group in the HP was successfully incorporated into the microgel, and the microgel was non-leaching, with the potential to keep its properties after contacting skin. Furthermore, the microgel was found to be non-cytotoxic and showed improved cell adherence to both mouse fibroblast and human keratinocyte cells as well as wound healing in a mouse model. Consequently, this study presents a novel non-leaching wound microgel that could be an effective regenerative dressing material for improving wound healing.
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