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Over half of the human cancers have been shown to express an activated form of the Ras gene. The newly discovered oncogenic forms of H-ras (H-rasA, H-rasC, and H-ras6) contain activating point mutations in H-ras. These mutations are localized to codons 12 and 13 of H-ras, and generate a series of Glu-X-Asp (GED) amino acid motifs, where X is any amino acid. The GED motifs contribute to transforming ability and are recognized by the oncoprotein “SOS” which in turn phosphorylates critical cytoplasmic effector proteins. The different H-ras-derived oncogenes are differentially expressed in various tissues and are dependent on the choice of an initiating oncogenic mutation. Cancer-initiating mutations in H-ras have been found in the lung, pancreas, colon, liver, ovary, and kidney; however, none have been identified in the breast, suggesting tissue-specific differences in the progression of oncogenic ras transformation.Aldershot East & Farnborough
The Aldershot East & Farnborough Divisional Internal Railway was a branch of the Great Western Railway which ran from Aldershot to Farnborough, Berkshire. It connected with the rest of the railway system at Aldershot East Junction.
History
The line was built by the Great Western Railway and opened in 1857. The line closed to freight in 1968, and closed to passengers in 1972.
Lines
The line linked with the Aldershot to Andover Line at Aldershot Junction near the Victoria Gate on the west, and Basingstoke to Aldershot (A340) Line at Aldershot East Junction. The line is signed F as it crosses the M3 motorway.
The route
The line leaves the main line at the Victoria Gate. Here the line crosses the M3 motorway and runs north over Newport Bridge. Leaving the motorway the line crosses the Ashley Boulevard before entering the Aldershot Shopping Area. The line then connects with the Basingstoke to Aldershot Line just south of the town’s main station.
Manchali is a 1973 Hindi romantic drama movie produced and directed by Raja Nawathe, and starring Sanjeev Kumar, Leena Chandavarkar, .
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Manchali is a 1973 Hindi romantic drama movie produced and directed by Raja Nawathe, and starring Sanjeev Kumar, Leena Chandavarkar, .
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Manchali is a 1973 Hindi romantic drama movie produced and directed by Raja Nawathe, and starring Sanjeev Kumar, Leena Chandavarkar, .
Manchali is a 1973 Hindi romantic drama movie produced and directed by Raja Nawathe, and starring Sanjeev Kumar, Leena Chandavarkar, .
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The current guidelines recommend the use of anti-reflux procedures during laparoscopic Heller myotomy with antireflux surgery (LHMAAS) for the treatment of achalasia. However, the volume of the exposed antirefluxing segment increases after LHMAAS, and the penetration of refluxate into this segment may eventually lead to myocardial ischemia. We evaluated whether this penetration of refluxate may occur in LHMAAS. We studied 15 patients (14 females; 1 male) with an average age of 54.8 years undergoing LHMAAS for achalasia at the authors’ institution during 2009. We measured the refluxing segment of the Heller myotomy, the blood flow of the exposed segment, the blood flow of the esophagus before and after the Heller myotomy, the visual grade of esophageal stenosis, and the blood flow of the stomach. After the myotomy was completed, the blood flow of the refluxing segment decreased to 2.6 ± 3.1 mL/min (range, 0.04-14.3 mL/min). However, the blood flow of the exposed segment increased to 44.2 ± 7.8 mL/min (range, 36.0-62.7 mL/min). The blood flow of the esophagus did not change. All patients had esophageal manometry prior to the myotomy and had low-amplitude esophageal contractions, and the average LES pressure was 9.2 ± 5.6 mm Hg. On the basis of the low-amplitude contractions and the LES pressure, the patients were diagnosed with achalasia. The exposed segment after the myotomy was the last 4 cm, which constitutes approximately 25% of the myotomy. One patient was reported to have esophageal ischemia 3 months after the procedure because the exposed segment showed ischemia that extended into the antrum. This study demonstrated that the volume of the refluxing segment after the antireflux surgery was much greater than that of the exposed segment. Moreover, the blood flow of the exposed segment after the myotomy increased significantly. These phenomena may cause a risk of ischemia of the
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