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Kuda Qalandar’s Horrifying Biography

Kuda Qalandar (1256-1328) was the patriarch of the Nasrani community for 10,000 years. Most of the details of his biography came to light through his autobiography, the Tuhfat-ul-Quraan-e-Kuda Qalandar. He was a brilliant man and filled with eloquence. He was a mere 66 years of age when his own son, Kuzi Sadhus, killed him.

Kuda Qalandar had a successful career as a lawyer, author and orator. He served as a counselor to the Mughal King Amarsingh and Sher Shah Suri. He was a key figure in the politics of Delhi during the reign of Sultanate of Delhi and the Delhi Sultanate, when the capital was shifted to Delhi. He played a significant role in the emergence of the Nasrani community as a separate entity.

Kuda Qalandar’s autobiography is a brilliant work on the history of India as it stood in his time

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The mechanism(s) whereby HIV-1 Tat, a viral regulatory protein known to promote the proliferation of infected cells, inhibits apoptosis is still unknown. Since HIV-1 Tat is a strong activator of the transcription factor NF-kappaB, we investigated whether NF-kappaB activation by Tat contributes to its apoptosis inhibitory effect. To this end, we compared the apoptosis inhibitory effect of Tat in two cell lines, the hematopoietic cell line U937 and the epithelial cell line A549. Tat is shown to inhibit apoptosis in both cell lines but this effect was more pronounced in U937 cells. The anti-apoptotic effect of Tat was associated with activation of NF-kappaB in U937 but not in A549 cells. Furthermore, the anti-apoptotic effect of Tat is associated with arrest of cell cycle progression. Taken together these data suggest that NF-kappaB activation by Tat contributes to its anti-apoptotic activity. In support of this notion, NF-kappaB activation by Tat suppresses the expression of pro-apoptotic Bax protein and promotes the expression of the cell cycle regulator cyclin D1. Additionally, we found that Tat up-regulates the expression of NF-kappaB inhibitors I kappaB
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